DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e2 and CYP86A1

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_200694.1	Gene:	CYP86A1 / 836003	AraportID:	AT5G58860	Length:	513	Species:	Arabidopsis thaliana

Alignment Length:	573	Identity:	142/573 - (24%)
Similarity:	229/573 - (39%)	Gaps:	128/573 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YIFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQYGKDN 70
            |...||.:..:.:..||        .:..||:.||.:|:...:..|.|.|        |.:..||
plant    11 YAVAALSVYALWFYFLS--------RRLTGPKVLPFVGSLPYLIANRSRI--------HDWIADN 59

  Fly    71 FVFWIGTYSNVLVTSSKYLEFILSSQ--------------TLITKSDIYQLTHPW-------LGL 114
            .....|||.    |.:..:.|:..:|              .|.|:.|.|.....|       ||.
plant    60 LRATGGTYQ----TCTMVIPFVAKAQGFYTVTCHPKNVEHILKTRFDNYPKGPMWRAAFHDLLGQ 120

  Fly   115 GLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKH-----LKTVAAGDNIFDFQEQA 174
            |:..|.|..|...||  |.|..|. .:...:.|.......||:     |......:...|.|:..
plant   121 GIFNSDGDTWLMQRK--TAALEFT-TRTLRQAMARWVNGTIKNRLWLILDRAVQNNKPVDLQDLF 182

  Fly   175 HYLTLDVICDTAMG-----VSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYP 234
            ..||.|.||....|     :|::..:|..|        :.::....|  .|||  |||.     .
plant   183 LRLTFDNICGLTFGKDPETLSLDLPDNPFS--------VAFDTATEA--TLKR--LLYT-----G 230

  Fly   235 AYSRTLKTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTIDGRPLNSKELYE 299
            ...|..|.:...:.:.:.|.:|     .|.|...|....:|.:..|.|||..:..|.:|...|..
plant   231 FLWRIQKAMGIGSEDKLKKSLE-----VVETYMNDAIDARKNSPSDDLLSRFLKKRDVNGNVLPT 290

  Fly   300 EV-----STFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKE----QREVMGNSE---LGRDATF 352
            :|     ..|:..|.||::..:|:..:|:..:::.:.|:..|    .:|..||.:   ......|
plant   291 DVLQRIALNFVLAGRDTSSVALSWFFWLVMNNREVETKIVNELSMVLKETRGNDQEKWTEEPLEF 355

  Fly   353 QEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVF-KD 415
            .|..::.||...:.|..|:|||||...::...|.|: ||..||:|:|:...:..:|..:.:: :|
plant   356 DEADRLVYLKAALAETLRLYPSVPQDFKYVVDDDVLPDGTFVPRGSTVTYSIYSIGRMKTIWGED 420

  Fly   416 PHKFRP--------ERFELEKPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALD 472
            ..:|||        ||||..|.| :::|.|:||||.|:|:..|..::|:|.|.::..:.|.|
plant   421 CLEFRPERWLTADGERFETPKDG-YKFVAFNAGPRTCLGKDLAYNQMKSVASAVLLRYRVFP--- 481

  Fly   473 ELVSKDGYISTTIGLPDAERKKRDPYRHKYDPILSAVLTLKSENGLYIRLKER 525
                          :|.          |:.:..:|  |||..:|||.:.|:.|
plant   482 --------------VPG----------HRVEQKMS--LTLFMKNGLRVYLQPR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	125/486 (26%)
CYP86A1	NP_200694.1	CYP86A	70..501	CDD:410687	118/485 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920