DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e2 and CYP86A2

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_191946.1	Gene:	CYP86A2 / 828019	AraportID:	AT4G00360	Length:	553	Species:	Arabidopsis thaliana

Alignment Length:	571	Identity:	133/571 - (23%)
Similarity:	221/571 - (38%)	Gaps:	124/571 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQYGKDNFVFWIGT 77
            :||||.:.......:|:.....|||..|::|:...:.:....:        |.:..:|.....||
plant     7 MLLVAVVAAYWLWFQRISRWLKGPRVWPVLGSLPGLIEQRDRM--------HDWITENLRACGGT 63

  Fly    78 YSNVLVTSSKYLEFILSSQTLIT--------------------KSDIYQ-LTHPWLGLGLLTSTG 121
            |...:..    :.|:...|.|:|                    |...:| :.|.:||.|:..|.|
plant    64 YQTCICA----VPFLAKKQGLVTVTCDPKNIEHMLKTRFDNYPKGPTWQAVFHDFLGQGIFNSDG 124

  Fly   122 SKWHKHRKMITPAFHF---NILQDFHEVMNEN-STKFIKHLKTVAAGDNIFDFQEQAHYLTLDVI 182
            ..|...||  |.|..|   .:.|.....:|.. ..:|...|:|........|.|:....||.|.|
plant   125 DTWLFQRK--TAALEFTTRTLRQAMGRWVNRGIKLRFCPILETAQNNYEPVDLQDLILRLTFDNI 187

  Fly   183 CDTAMGVSINAM-----ENRSSSIVQAFKDMCYNINMRAF-HPLKRNELLYRLAPDY-----PAY 236
            |..|.|......     ||..:|   || |.....:::.| .|    |.|:||....     .:.
plant   188 CGLAFGKDTRTCAPGLPENGFAS---AF-DRATEASLQRFILP----EFLWRLKKWLGLGLEVSL 244

  Fly   237 SRTLKTLQDFTNEIIAKR----IEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTIDGRPLNSKEL 297
            ||:|..:..:.:.:|..|    :...:||   ....|:...:.|...|...|.|.         |
plant   245 SRSLGEIDGYLDAVINTRKQELLSQRESG---VQRHDDLLSRFMKKKDQSYSETF---------L 297

  Fly   298 YEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDAT--------FQE 354
            ......|:..|.||::..:|:..:|::.|...:.|:.:|...|:..:. |.|.:        |.|
plant   298 RHVALNFILAGRDTSSVALSWFFWLITTHPTVEDKIVREICSVLIETR-GTDVSSWTAEPLEFDE 361

  Fly   355 ISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVF-KDPH 417
            :.::.||...:.|..|:|||||...:....|.:: ||..||.|:::...:...|..:..: :|..
plant   362 VDRLVYLKAALSETLRLYPSVPEDSKHVVNDDILPDGTFVPAGSSVTYSIYAAGRMKSTWGEDCL 426

  Fly   418 KFRPERFELEKPGPF------EYVPFSAGPRNCIGQKFALLEIKTVVSKII--RNFEVLPALDEL 474
            :|:|||:.....|.|      .:|.|:||||.|:|:..|.|::||:.:.::  ....|.|.
plant   427 EFKPERWISPDDGKFVNHDQYRFVAFNAGPRICLGKDLAYLQMKTIAAAVLLRHRLTVAPG---- 487

  Fly   475 VSKDGYISTTIGLPDAERKKRDPYRHKYDPILSAVLTLKSENGLYIRLKER 525
                                     ||.:..:|  |||..:|||.:.:.:|
plant   488 -------------------------HKVEQKMS--LTLFMKNGLLVNVHKR 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	117/491 (24%)
CYP86A2	NP_191946.1	CYP86A	67..504	CDD:410687	115/494 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920