DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and CYP72A11

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_188083.1	Gene:	CYP72A11 / 820693	AraportID:	AT3G14650	Length:	512	Species:	Arabidopsis thaliana

Alignment Length:	515	Identity:	135/515 - (26%)
Similarity:	232/515 - (45%)	Gaps:	99/515 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWFVLYIFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKN----------PSEI 55
            :||       .|.:|.:||      ||:.|   .|....||:|:   :.||          |..:
plant    28 VWF-------KPKMLESYL------RRQGL---AGTPYTPLVGD---LKKNFSMRAEARSKPINL 73

  Fly    56 LDTV--------FSWWHQYGKDNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSDIYQLTHPWL 112
            .|.:        ......:|: .|..|.|....:.:...:.:..:|:......|:..:.|.. .:
plant    74 TDDITPRIVPYPLQMLKTHGR-TFFTWFGAIPTITIMDPEQITEVLNKVYDFQKAHTFPLGR-LI 136

  Fly   113 GLGLLTSTGSKWHKHRKMITPAFHF----NILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQ 173
            ..|:|:..|.||.|||::|.||||.    |::..||:..:|...|:.|.:....:...: |....
plant   137 ATGVLSYDGDKWAKHRRIINPAFHLEKIKNMVPAFHQSCSEIVCKWDKLVSDKESSCEV-DVWPG 200

  Fly   174 AHYLTLDVICDTAMGVSINAMENRSSSIVQA-FKDMCYNINMRAFHPLKRNELLYRLAPDYPAYS 237
            ...:|.|||..||.|.|  .:|.:....:|| ...:......:||               .|.||
plant   201 LVSMTADVISRTAFGSS--CVEGQRIFELQAELAQLIIQTVRKAF---------------IPGYS 248

  Fly   238 -------RTLKT----LQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTI---D 288
                   |.:|.    :|.....|:.||:.|.::|....:          ..|..||.|.:   .
plant   249 YLPTKGNRRMKAKAREIQVILRGIVNKRLRAREAGEAPND----------DLLGILLESNLGQTK 303

  Fly   289 GRPLNSKELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQ 353
            |..:::::|.||...|.|.|.:||:..:.:.:.|||:|||.|.:..:|.::|.|:.|  .||  :
plant   304 GNGMSTEDLMEECKLFYFVGQETTSVLLVWTMVLLSQHQDWQARAREEVKQVFGDKE--PDA--E 364

  Fly   354 EISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVIDGDL-VPKGTTLNLGLVMLGYNEKVF-KDP 416
            .::|:|.:.:.:.|..|:||.:|.:.|...|:..: ||| :|.|..:||.::::..:.::: .|.
plant   365 GLNQLKVMTMILYEVLRLYPPIPQLSRAIHKEMEL-GDLTLPGGVLINLPILLVQRDTELWGNDA 428

  Fly   417 HKFRPERFE--LEK--PGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIR--NFEVLPA 470
            .:|:|:||:  |.|  .....:.||:.|.|.||||.|||||.|..::.|::  :||:.|:
plant   429 GEFKPDRFKDGLSKATKNQASFFPFAWGSRICIGQNFALLEAKMAMALILQRFSFELSPS 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	125/478 (26%)
CYP72A11	NP_188083.1	p450	24..512	CDD:299894	135/515 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.860