DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e2 and CYP704A2

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_182075.1	Gene:	CYP704A2 / 819159	AraportID:	AT2G45510	Length:	511	Species:	Arabidopsis thaliana

Alignment Length:	543	Identity:	135/543 - (24%)
Similarity:	223/543 - (41%)	Gaps:	83/543 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQYGKDNF 71
            ||:.|...:...:.:.|.:.|      |..|..|:......:..:..|:.|  :.......|..:
plant    15 IFIVLCFTIYLMIRIFTGKSR------NDKRYAPVHATVFDLLFHSDELYD--YETEIAREKPTY 71

  Fly    72 VFWIGTYSNVLVTSSKYLEFILSSQTLITKSDIYQLTH-------PWLGLGLLTSTGSKWHKHRK 129
            .|.....|.:|....:.:|.||.     |:.|.|...|       ..||.|:....|.||.:.||
plant    72 RFLSPGQSEILTADPRNVEHILK-----TRFDNYSKGHSSRENMADLLGHGIFAVDGEKWRQQRK 131

  Fly   130 MITPAFHFNILQDFH-EVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMGVSINA 193
            :.:..|...:|:||. .|...|::|.:..:...|.....||.|:.....|||.|.....||.:..
plant   132 LSSFEFSTRVLRDFSCSVFRRNASKLVGFVSEFALSGKAFDAQDLLMRCTLDSIFKVGFGVELKC 196

  Fly   194 MENRS---SSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIA--- 252
            ::..|   ...::||.:.....:.|...||.:.:..:.:. ......:::.|:..|...:|.
plant   197 LDGFSKEGQEFMEAFDEGNVATSSRFIDPLWKLKWFFNIG-SQSKLKKSIATIDKFVYSLITTKR 260

  Fly   253 KRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTIDGRPLNSKELYEEVSTFMFEGHDTTTSGVS 317
            |.:...::..|..:....|          |:.|..|...:|.|.|.:.:..||..|.|||.:.:|
plant   261 KELAKEQNTVVREDILSRF----------LVESEKDPENMNDKYLRDIILNFMIAGKDTTAALLS 315

  Fly   318 FAVYLLSRHQDEQRKLFKEQREVMGNSELGRDAT-FQE------ISQMKYLDLFIKEAQRVYPSV 375
            :.:|:|.::...|.|:.:|.|:|..:.|...|.. |.|      :.:|.||...:.|..|:||.|
plant   316 WFLYMLCKNPLVQEKIVQEIRDVTFSHEKTTDVNGFVESINEEALDEMHYLHAALSETLRLYPPV 380

  Fly   376 PFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVF-KDPHKFRPER------FELEKPGPF 432
            |...|..|.|.|: ||..|.||..:......:|....:: :|..:|:|||      |:.|  .||
plant   381 PVDMRCAENDDVLPDGHRVSKGDNIYYIAYAMGRMTYIWGQDAEEFKPERWLKDGLFQPE--SPF 443

  Fly   433 EYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDP 497
            :::.|.||||.|:|:.||..::| :||..:.:|......|| .||..|             ||
plant   444 KFISFHAGPRICLGKDFAYRQMK-IVSMALLHFFRFKMADE-NSKVYY-------------KR-- 491

  Fly   498 YRHKYDPILSAVLTLKSENGLYI 520
                       :|||..:.||::
plant   492 -----------MLTLHVDGGLHL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	117/462 (25%)
CYP704A2	NP_182075.1	PLN03195	15..509	CDD:215627	135/543 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920