DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001003947.1	Gene:	Cyp4x1 / 81906	MGIID:	1932403	Length:	507	Species:	Mus musculus

Alignment Length:	536	Identity:	153/536 - (28%)
Similarity:	260/536 - (48%)	Gaps:	64/536 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LYIFLALPLLLVAYLELSTFRRR--RVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQYG 67
            |.:...|.|:|:..::|...|:|  |.|:.|.||....|:|:...:.::..|.||.:.. .|...
Mouse    16 LALVFCLALVLMQAMKLYLRRQRLLRDLSPFPGPPAHWLLGHQKFLQEDNMETLDEIVK-KHPCA 79

  Fly    68 KDNFVFWIGTYSNVL-VTSSKYLEFILSSQTLITKSD-----IYQLTHPWLGLGLLTSTGSKWHK 126
               |..|:|.:.... :....|.:..||      ::|     ::||..|.:|.|||...|.:|.:
Mouse    80 ---FPCWVGPFQAFFYIYDPDYAKIFLS------RTDPKMQYLHQLLTPCIGRGLLNLDGPRWFQ 135

  Fly   127 HRKMITPAFHFNILQDFHEVMNENSTKFI--KHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMGV 189
            ||.::|||||.:||:...:.| .:|.|.:  |..|.....:...:..|..:.:|||:|...|.|.
Mouse   136 HRCLLTPAFHQDILKPCVDTM-AHSVKVMLDKWEKMWTTQETTIEVFEHINLMTLDIIMKCAFGQ 199

  Fly   190 SINAMENRS-SSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAK 253
            ..|...|.: .|.|:|..::...|:.|.::....::::::|:|....:....|.:..:|.:||..
Mouse   200 ETNCQINGTYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGKVIHQYTEKIIQD 264

  Fly   254 RIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTI-DGRPLNSKELYEEVSTFMFEGHDTTTSGVS 317
            |.:..|:     ....:.|:....|||.:||:.. |.|..:..:|..||:|||:.|||.:.:.:|
Mouse   265 RKKILKN-----QVKQDDTQTSQIFLDIVLSAQAEDERAFSDADLRAEVNTFMWAGHDASAASIS 324

  Fly   318 FAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFT 382
            :.:|.|:.:.:.|.:...|.|.::|:   |...|::::.:|.|..:.|||..|:.|.||.|.|..
Mouse   325 WLLYCLALNPEHQDRCRTEIRSILGD---GSSITWEQLDEMSYTTMCIKETLRLIPPVPSISREL 386

  Fly   383 EKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKPG---PFEYVPFSAGPRN 443
            .|...: ||..:|.|.|:.|.:..|.:|..|:.||..|.|.||..|...   |..::|||:||||
Mouse   387 SKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVWNDPKVFDPLRFTKENSDQRHPCAFLPFSSGPRN 451

  Fly   444 CIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDPILSA 508
            ||||:||:||:|..::.|:.:|:|.|.|..                             .|..|:
Mouse   452 CIGQQFAMLELKVAIALILLHFQVAPDLTR-----------------------------PPAFSS 487

  Fly   509 VLTLKSENGLYIRLKE 524
            ...|:.::|:|:.||:
Mouse   488 HTVLRPKHGIYLHLKK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	134/447 (30%)
Cyp4x1	NP_001003947.1	p450	47..499	CDD:278495	140/499 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845100
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750