DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_077764.2	Gene:	Cyp4f18 / 72054	MGIID:	1919304	Length:	524	Species:	Mus musculus

Alignment Length:	476	Identity:	141/476 - (29%)
Similarity:	240/476 - (50%)	Gaps:	63/476 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 KDNFVFWIGTYSNVL-VTSSKYLEFILSSQTLITKSD--IYQLTHPWLGLGLLTSTGSKWHKHRK 129
            :|...:|:|....|: :....:::.::.:..|:...|  .|:...||||.|||.|||.||.:||:
Mouse    85 RDACCWWVGPLHPVIRIFHPAFIKPVVLAPALVAPKDTVFYRFLKPWLGDGLLMSTGDKWSRHRR 149

  Fly   130 MITPAFHFNILQDFHEVMNENSTKFIKHLK---TVAAGDNIFDFQEQAHYLTLDVICDTAMGVSI 191
            |:|||||||||:.:.:|.|:::.  |.|.|   ..:.|....:..|....:|||.:.........
Mouse   150 MLTPAFHFNILKPYVKVFNDSTN--IMHAKWQRLASKGSAYLNMFEHISLMTLDSLQKCVFSFDS 212

  Fly   192 NAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAKR-- 254
            |..| :.|..:.|..::...:..|....|...:|.|.|..|...:.:..:.:.|||:.:|.:|
Mouse   213 NCQE-KPSEYITAILELSTLVARRHQRLLLHVDLFYYLTHDGMRFRKACRLVHDFTDAVIRERRR 276

  Fly   255 -------IEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTID-GRPLNSKELYEEVSTFMFEGHDT 311
                   ::..|:.|.:         |.:.|:|.||.|..: |:.|:.:::..|..||||.||||
Mouse   277 TLLDQGGVDVLKAKAKA---------KTLDFIDVLLLSKDEHGKALSDEDIRAEADTFMFGGHDT 332

  Fly   312 TTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVP 376
            |.||:|:.:|.|:||.:.|.:..:|.||::.:.| ..:..:.:::|:.:|.:.|||:.|::|.|.
Mouse   333 TASGLSWILYNLARHPEYQERCRQEVRELLRDRE-PEEIEWDDLAQLPFLTMCIKESLRLHPPVT 396

  Fly   377 FIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEK---PGPFEYVPF 437
            .|.|...:|.|: ||.::|||....:.:....:|..|:.||..:.|.||:.:.   ..|..::||
Mouse   397 AISRCCTQDIVLPDGRVIPKGVISRISIFGTHHNPAVWPDPEVYDPFRFDADNVKGRSPLAFIPF 461

  Fly   438 SAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKY 502
            ||||||||||.||:.|:|..::..:..|.|                   |||.:..:|.|
Mouse   462 SAGPRNCIGQTFAMSEMKVALALTLLRFRV-------------------LPDDKEPRRKP----- 502

  Fly   503 DPILSAVLTLKSENGLYIRLK 523
                  .|.|::|.||:::::
Mouse   503 ------ELILRAEGGLWLKVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	131/420 (31%)
Cyp4f18	NP_077764.2	p450	52..516	CDD:365848	141/473 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845244
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650