DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and Cyp4f16

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001343232.1	Gene:	Cyp4f16 / 70101	MGIID:	1917351	Length:	524	Species:	Mus musculus

Alignment Length:	555	Identity:	152/555 - (27%)
Similarity:	268/555 - (48%)	Gaps:	89/555 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WFVLYIFLALPLL--LVAYL--------ELSTFRRRRVLNKFNGPRGLPLMGNAH------QMGK 50
            |.:|.:.:|..:|  ::|:.        .||.|.:....|.|:|..|: :..|..      :||
Mouse    19 WHLLLLGVASWILARILAWTYSFYENCSRLSCFPQPPKKNWFSGHLGM-IQSNEEGMQLVTEMG- 81

  Fly    51 NPSEILDTVFSWWHQYGKDNFVFWIGTYSNVL-VTSSKYLEFILSSQTLITKSDI--YQLTHPWL 112
                          |..:|..:||:|....|| :....::..:|.:..|:...|:  .:...|||
Mouse    82 --------------QTFQDVHLFWLGPVIPVLRIVDPAFVAPLLQAPALVAPKDMTFLRFLKPWL 132

  Fly   113 GLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNEN----STKFIKHLKTVAAGDNIFDFQEQ 173
            |.||..|:|.||.:||:::||||||:||:.:.::.|::    ..|: |||.  :.|....:..|.
Mouse   133 GDGLFLSSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMHAKW-KHLS--SEGSARLEMFEH 194

  Fly   174 AHYLTLDVICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSR 238
            ...:|||.:.....|...|..|: .|..:.|..::...|..|:.......:.||....|...:.:
Mouse   195 ISLMTLDSLQKCLFGFDSNCQES-PSEYISAILELSSLIIKRSLQLFLFVDFLYYHTADGRRFRK 258

  Fly   239 TLKTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKK-----MAFLDTLLSSTID-GRPLNSKEL 297
            ....:.:||:.:|.:|  .|   .:|:...|||.:.|     :.|:|.||.:..: |:.|:.:::
Mouse   259 ACDLVHNFTDAVIRER--RH---TLSSQNHDEFLKSKTKSKTLDFIDVLLLAKDEHGKELSDEDI 318

  Fly   298 YEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLD 362
            ..|..||||.|||||.|.:|:.:|.|:||.:.|.:..:|.:|::.:.| ..:..:.:::|:.:|.
Mouse   319 RAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVQELLRDRE-PEEIEWDDLAQLPFLT 382

  Fly   363 LFIKEAQRVY-PSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFEL 426
            :.|||:.|:: |.:..:.|.|....:.||.::|||....:.:..:.:|..|:.||..:.|.||:.
Mouse   383 MCIKESLRLHSPVIDLLRRCTRDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDP 447

  Fly   427 EKP---GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLP 488
            |.|   .|..::||||||||||||.||:.|:|..::..:..|.:                   ||
Mouse   448 ENPQKRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRI-------------------LP 493

  Fly   489 DAERKKRDPYRHKYDPILSAVLTLKSENGLYIRLK 523
            |.:..:|.|           .:.|::|.||::|::
Mouse   494 DDKEPRRKP-----------EIILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	132/456 (29%)
Cyp4f16	NP_001343232.1	p450	52..514	CDD:306555	143/517 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845187
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640