Protein Alignment Cyp4e2 and CYP4F12

DIOPT Version :9

• Sequence 1: NP_001286196.1
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 156/558 - (27%)
• Similarity: 270/558 - (48%)
• Gaps: 95/558 - (17%)

  Fly     2 WFVLYI----FLALPLLLVAYLELSTFRRRRVL------NKFNGPRGL--PL---MGNAHQMGKN 51
            |.:|.:    :|...:|...|...:..||.:..      |.|.|..||  |.   :.|:.||...
Human    19 WLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGLKNSTQMSAT 83

  Fly    52 PSEILDTVFSWWHQYGKDNFVFWIGTYSNVLVTSSKYLEFIL------------SSQTLITKSDI 104
            .|:               .|..|:|          ..:.||:            :|..:..|.::
Human    84 YSQ---------------GFTVWLG----------PIIPFIVLCHPDTIRSITNASAAIAPKDNL 123

  Fly   105 Y-QLTHPWLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFI---KHLKTVAAGD 165
            : :...||||.|:|.|.|.||.:||:|:|||||||||:.:..:.|:::...:   :||  .:.|.
Human   124 FIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHL--ASEGS 186

  Fly   166 NIFDFQEQAHYLTLDVICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLA 230
            :..|..|....:|||.:.........:..| |.|..:....::...:..|:.|.|:..:.||.|:
Human   187 SRLDMFEHISLMTLDSLQKCIFSFDSHCQE-RPSEYIATILELSALVEKRSQHILQHMDFLYYLS 250

  Fly   231 PDYPAYSRTLKTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDT-LLSSTIDGRPLNS 294
            .|...:.|..:.:.|||:.:|.:|.....:..:.....|:...|.:.|:|. |||...||:.|:.
Human   251 HDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSD 315

  Fly   295 KELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMK 359
            :::..|..||||.|||||.||:|:.:|.|:||.:.|.:..:|.:|::.:.: .::..:.:::|:.
Human   316 EDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRD-PKEIEWDDLAQLP 379

  Fly   360 YLDLFIKEAQRVYPSVPFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPER 423
            :|.:.:||:.|::|..|||.|...:|.|: ||.::|||.|..:.::.:.:|..|:.||..:.|.|
Human   380 FLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFR 444

  Fly   424 FELEKP---GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTI 485
            |:.|..   .|..::||||||||||||.||:.|:|.|::.::.:|..||...|
Human   445 FDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTE------------ 497

  Fly   486 GLPDAERKKRDPYRHKYDPILSAVLTLKSENGLYIRLK 523
                 .|:|.:             |.:::|.||::|::
Human   498 -----PRRKLE-------------LIMRAEGGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	137/459 (30%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	145/512 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154827
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.650