Protein Alignment Cyp4e2 and CYP3A43

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 121/510 - (23%)
• Similarity: 221/510 - (43%)
• Gaps: 81/510 - (15%)

  Fly     6 YIFLALPLLLVAYLELSTFRRRRVLNKFN--GPRGLPLMGNAHQMGKNPSEILDTVFSWWH---- 64
            ::.:|..|:|   |.:......::..|..  ||..||.:|.          ||..:...|:
Human    12 WVLVATSLVL---LYIYGTHSHKLFKKLGIPGPTPLPFLGT----------ILFYLRGLWNFDRE 63

  Fly    65 ---QYGKDNFVFWIGTYSN----VLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLTSTGS 122
               :||:    .| |.|..    :::.....::.:|..:..    .::....|...:|.|.|..|
Human    64 CNEKYGE----MW-GLYEGQQPMLVIMDPDMIKTVLVKECY----SVFTNQMPLGPMGFLKSALS 119

  Fly   123 -----KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVI 182
                 :|.:.|.:::|||.....::...::::.....::.|:..|......:.::.....|:|||
Human   120 FAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184

  Fly   183 CDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTL---- 243
            ..|..||:::::.|.....::         ||:....|...:....|...:|..:...:.|
Human   185 TGTLFGVNLDSLNNPQDPFLK---------NMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240

  Fly   244 --QDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSS-----TIDGRPLNSKELYEEV 301
              :|.|: .:...||..|...:.     :..:.::.|...::.|     |...:.|:..||..:.
Human   241 FPKDVTH-FLKNSIERMKESRLK-----DKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQS 299

  Fly   302 STFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIK 366
            ...:|..:|||::.:.|.:|.|:.|.|.|:||.:|...|:.|.   ...|:..:.||:|||:.:.
Human   300 IIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNK---APVTYDALVQMEYLDMVVN 361

  Fly   367 EAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPE-RFELEKPG 430
            |..|::|.|..:.|..:||..|:|..:|||..:.:.:..|.::.|.:.:|.||.|| ||..:...
Human   362 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKD 426

  Fly   431 P---FEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPA--------LDEL 474
            .   :.|:||.||||||||.:|||..||..|.:.::||...|.        ||.|
Human   427 SIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	106/439 (24%)
CYP3A43	NP_073731.1	cytochrome_P450	67..493	CDD:477761	108/442 (24%)