DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	510	Identity:	121/510 - (23%)
Similarity:	221/510 - (43%)	Gaps:	81/510 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YIFLALPLLLVAYLELSTFRRRRVLNKFN--GPRGLPLMGNAHQMGKNPSEILDTVFSWWH---- 64
            ::.:|..|:|   |.:......::..|..  ||..||.:|.          ||..:...|:
Human    12 WVLVATSLVL---LYIYGTHSHKLFKKLGIPGPTPLPFLGT----------ILFYLRGLWNFDRE 63

  Fly    65 ---QYGKDNFVFWIGTYSN----VLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLTSTGS 122
               :||:    .| |.|..    :::.....::.:|..:..    .::....|...:|.|.|..|
Human    64 CNEKYGE----MW-GLYEGQQPMLVIMDPDMIKTVLVKECY----SVFTNQMPLGPMGFLKSALS 119

  Fly   123 -----KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVI 182
                 :|.:.|.:::|||.....::...::::.....::.|:..|......:.::.....|:|||
Human   120 FAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184

  Fly   183 CDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTL---- 243
            ..|..||:::::.|.....::         ||:....|...:....|...:|..:...:.|
Human   185 TGTLFGVNLDSLNNPQDPFLK---------NMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240

  Fly   244 --QDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSS-----TIDGRPLNSKELYEEV 301
              :|.|: .:...||..|...:.     :..:.::.|...::.|     |...:.|:..||..:.
Human   241 FPKDVTH-FLKNSIERMKESRLK-----DKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQS 299

  Fly   302 STFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIK 366
            ...:|..:|||::.:.|.:|.|:.|.|.|:||.:|...|:.|.   ...|:..:.||:|||:.:.
Human   300 IIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNK---APVTYDALVQMEYLDMVVN 361

  Fly   367 EAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPE-RFELEKPG 430
            |..|::|.|..:.|..:||..|:|..:|||..:.:.:..|.::.|.:.:|.||.|| ||..:...
Human   362 ETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKD 426

  Fly   431 P---FEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPA--------LDEL 474
            .   :.|:||.||||||||.:|||..||..|.:.::||...|.        ||.|
Human   427 SIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	112/464 (24%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	116/480 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810