DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e2 and Cyp4f14

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001191262.1	Gene:	Cyp4f14 / 64385	MGIID:	1927669	Length:	524	Species:	Mus musculus

Alignment Length:	544	Identity:	163/544 - (29%)
Similarity:	275/544 - (50%)	Gaps:	67/544 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WFVLYIFLALPLLLVAYLEL-STFRRRRVLNKF-NGPRGLPLMGNAHQMGKNPSE----ILDTVF 60
            |..|.:..|..:|....::: :.:|..|.|:.| ..|:...|||:...:  .|:|    .|..:.
Mouse    19 WKTLLLLGASWILARILIQIYAAYRNYRHLHGFPQPPKRNWLMGHVGMV--TPTEQGLKELTRLV 81

  Fly    61 SWWHQYGKDNFVFWIGTYSNVL-VTSSKYLEFILSSQTLITKSDI--YQLTHPWLGLGLLTSTGS 122
            ..:.|    .|:.|||....|: :..|..:..||::...:...|:  |.:..||||.|||.|.|.
Mouse    82 GTYPQ----GFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDVIFYSILKPWLGDGLLVSAGD 142

  Fly   123 KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLK---TVAAGDNIFDFQEQAHYLTLDVICD 184
            ||.:||:|:|||||||||:.:.::.|:::.  |.|.|   .::.|....|..|....:|||.:..
Mouse   143 KWSRHRRMLTPAFHFNILKPYVKIFNDSTN--IMHAKWQRLISDGSARLDMFEHVSLMTLDSLQK 205

  Fly   185 TAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNE 249
            .......|..| :||..:.|..::...:..|...||...:|||.|.||...:.:....:.:||:.
Mouse   206 CVFSFDSNCQE-KSSEYIAAILELSALVAKRHQQPLMFMDLLYNLTPDGMRFRKACNVVHEFTDA 269

  Fly   250 IIAKRIEAHKSGAVSTNAGDEFTRKK-----MAFLDT-LLSSTIDGRPLNSKELYEEVSTFMFEG 308
            :|.:|   |::  :.....|:|.:.|     :.|:|. |||...||:.|:.:::..|..||||||
Mouse   270 VIRER---HRT--LPDQGLDDFLKSKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEG 329

  Fly   309 HDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYP 373
            ||||.||:|:.:|.|:||.:.|.:..:|.:|::...| ..:..:.:::|:.:|.:.|||:.|::|
Mouse   330 HDTTASGLSWILYNLARHPEYQERCRQEVQELLRGRE-PEEIEWDDLAQLPFLTMCIKESLRLHP 393

  Fly   374 SVPFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFE---LEKPGPFEY 434
            .|..|.|...:|.:: ||..:|||....:.:..:.:|..|:.||..:.|.||:   ::...|..:
Mouse   394 PVTVISRCCTQDILLPDGRTIPKGIICLISIFGIHHNPSVWPDPEVYDPFRFDPENIKDSSPLAF 458

  Fly   435 VPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYR 499
            :||||||||||||.||:.|:|..::..:..|.:                   |||.:..:|.|
Mouse   459 IPFSAGPRNCIGQTFAMSEMKVALALTLLRFRL-------------------LPDDKEPRRQP-- 502

  Fly   500 HKYDPILSAVLTLKSENGLYIRLK 523
                     .|.|::|.||::|::
Mouse   503 ---------ELILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	144/453 (32%)
Cyp4f14	NP_001191262.1	p450	52..511	CDD:365848	152/503 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845227
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650