DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and zgc:123299

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	XP_021324190.1	Gene:	zgc:123299 / 641477	ZFINID:	ZDB-GENE-051120-33	Length:	501	Species:	Danio rerio

Alignment Length:	496	Identity:	127/496 - (25%)
Similarity:	228/496 - (45%)	Gaps:	64/496 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WFVLYIFLALPLLLVAYLELSTFRRRRVLNKFNG-PRGLPLMGNAHQMGK----NPSEILDTVFS 61
            :.:||:..|:.....||. |......:..:...| ||...|:|::..:.|    :.|.|.|....
Zfish     8 YIILYLLAAVFTAFFAYC-LYVHHIHQKYDHIPGPPRDNFLLGHSPSLTKALYSDDSLIYDLFLQ 71

  Fly    62 WWHQYGKDNFVFWIGT--YSNVLVTSSKYLEFILSSQTLITKSDIYQ-----LTHPWLGLGLLTS 119
            |..:||.   |:.|.|  |..::|...:..:.|:.|........:|:     ....:||.||:|:
Zfish    72 WAEKYGP---VYRINTLHYVTIVVYCPEATKTIMMSPKYTKDPFVYRRVFNLFGKRFLGYGLITA 133

  Fly   120 TGSK-WHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVIC 183
            .... |::.|:::.|||..:.|:......:|.|.:.:..|:.:|.........:..:.:||||||
Zfish   134 VDHDIWYRQRRIMDPAFSSSYLRSLISTFDEMSERLMDKLEEIANNKTPAVMHDLVNCVTLDVIC 198

  Fly   184 DTAMGVSINAMENRSSSIVQA----FKDMCYNINMRAFHPLKRN-----------ELLYRLAPDY 233
            ..|.||.:|.:..:.|....|    .|.|.:::....|..:.:|           |||.:....:
Zfish   199 KVAFGVDLNFLTQKDSPFQNAVELCLKGMTFDVRDPLFRIIPKNWKLIQQVREATELLRKTGEKW 263

  Fly   234 PAYSRT-LKTLQDFTNEIIAKRIE-AHKSGAVSTNAGDEFTRKKMAFLDTLLSSTIDGRPLNSKE 296
            ....:| :|..:|...:|:.:.:: |.:....||   ::|                       ::
Zfish   264 IQNRKTAVKNGEDVPKDILTQILKSAEEQNVTST---EDF-----------------------EQ 302

  Fly   297 LYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYL 361
            :.:...||...|.:||.:.:|||:..|.|:.:..::...|..||:|..   |:.:.:::.::.||
Zfish   303 MLDNFVTFFMAGQETTANQLSFAIMELGRNPEIYKRAKAEVDEVLGTK---REISNEDLGKLTYL 364

  Fly   362 DLFIKEAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFEL 426
            ...:||..|:||:.|...|:..:|.:|:|..:|.|.::.....:....||.||||.||.|:||:.
Zfish   365 SQVLKETLRLYPTAPGTNRWLHEDMIINGIKIPGGCSVMFNSFVSQRLEKFFKDPLKFDPKRFDE 429

  Fly   427 EKPGP-FEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFE 466
            ..|.| :.|.||:.|||.||||.|:.:|.|.|::|:::.||
Zfish   430 NAPKPYYTYYPFALGPRTCIGQVFSQMEAKVVLAKLLQRFE 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	121/463 (26%)
zgc:123299	XP_021324190.1	p450	39..495	CDD:306555	121/464 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820