DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	XP_006524820.1	Gene:	Cyp4f40 / 631304	MGIID:	3645508	Length:	551	Species:	Mus musculus

Alignment Length:	545	Identity:	158/545 - (28%)
Similarity:	268/545 - (49%)	Gaps:	79/545 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WFVLYIFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMG-KNPSEILDTVFSWWHQ 65
            ||:......|..|......|..|.:....|.|.|..|   |....:.| |..:|::.|.
Mouse    56 WFLARFLTQLYTLYAKCQRLCGFPQPPKKNWFWGHLG---MSPPTEEGMKQVTELVTTY------ 111

  Fly    66 YGKDNFVFWIGTYSNVL-VTSSKYLEFILSSQTLIT-KSDI-YQLTHPWLGLGLLTSTGSKWHKH 127
              ...|:.|:|....:: :.....:..:||:...:. |.|| |....||||.|||.|.|.||::|
Mouse   112 --PQGFMTWLGPIVPLITLCHPDIIRSVLSASAAVAPKDDIFYSFLKPWLGDGLLVSAGDKWNRH 174

  Fly   128 RKMITPAFHFNILQDFHEVMNENSTKFI--KHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMGVS 190
            |:|:|||||||||:.:.::.|: ||..:  |.|:..:.|....:..|....:|||.:.......:
Mouse   175 RRMLTPAFHFNILKPYVKIFND-STNIMHAKWLRLASGGSTRLNMFENISLMTLDTLQKCVFSFN 238

  Fly   191 INAMENRSSSIVQAFKDMCYNINMRAFHPLKRNE-------LLYRLAPDYPAYSRTLKTLQDFTN 248
            .|..| :.|..:.|..::       :...:||||       |||||.||...:.:..:.:.|||:
Mouse   239 SNCQE-KPSQYIAAILEL-------STLAVKRNEQLLMHVDLLYRLTPDGMRFYKACRLVHDFTD 295

  Fly   249 EIIAKRIEAHKSGAVSTNAGDEFTR-----KKMAFLDT-LLSSTIDGRPLNSKELYEEVSTFMFE 307
            .:|.:|     ...:..:.||:..:     |.:.|:|. ||:...||:.|:.:::..|..||||.
Mouse   296 AVIQER-----RRTLLKHGGDDIIKAKAKSKTLDFIDVLLLTKDEDGKELSDEDIRAEADTFMFR 355

  Fly   308 GHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVY 372
            |||||.||:|:.:|.|:||.:.|.:..:|.:|::.:.: .::..:.:::|:.:|.:.|||:.|::
Mouse   356 GHDTTASGLSWILYNLARHPEHQERCRQEVQELLRDRD-PKEIEWDDLAQLPFLTMCIKESLRLH 419

  Fly   373 PSVPFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFE---LEKPGPFE 433
            |.|..:.|...:|..: ||.::|||....:.:....:|..|::||..:.|.||:   ::...|..
Mouse   420 PPVTMVSRCCTQDISLPDGRIIPKGVICIINIFGTHHNPTVWRDPEVYDPFRFDPENIQARSPLS 484

  Fly   434 YVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPY 498
            ::||||||||||||.||:.|:|..::..:..|.:                   |||.:..:|.|
Mouse   485 FIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRI-------------------LPDDKEPRRKP- 529

  Fly   499 RHKYDPILSAVLTLKSENGLYIRLK 523
                      .|.|::|.||::|::
Mouse   530 ----------ELILRAEGGLWLRVE 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	139/456 (30%)
Cyp4f40	XP_006524820.1	p450	79..542	CDD:365848	151/518 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845228
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650