DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and Cyp3a57

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001093650.1	Gene:	Cyp3a57 / 622127	MGIID:	3646373	Length:	503	Species:	Mus musculus

Alignment Length:	462	Identity:	119/462 - (25%)
Similarity:	218/462 - (47%)	Gaps:	61/462 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GPRGLPLMGNAHQMGKNPSEILDTVFSWW-------HQYGKDNFVFWIGTYSNVLVTSSKYLEFI 92
            ||:.|||.||          |::.:...|       .:||| .:.|:.|....:.:...:.::.:
Mouse    40 GPKPLPLFGN----------IINYLDGMWKFDDDCYKKYGK-IWGFYEGPQPILAIMDPEIIKIV 93

  Fly    93 LSSQTLITKSDIYQLTHPWLGLGLL-----TSTGSKWHKHRKMITPAFHFNILQDFHEVMNENST 152
            |..:..    .::....|:..:|.|     .|...:|.:.|.:::|.|..:.|::...:|.:...
Mouse    94 LVKECY----SVFTNRRPFGPVGFLKKSITISEDEEWKRLRTLLSPTFTSSKLKEMFPIMRQYGD 154

  Fly   153 KFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAF 217
            ..:::|:.....:...:.::.....::|||..|:.||:|:::.|.....||..|.:   :..:.|
Mouse   155 ILVRNLRREEEKEEPINMKDIFGAYSMDVITGTSCGVNIDSLNNPQDPFVQKIKKI---LKFKFF 216

  Fly   218 HPLKRNELLYR-LAPDYPAYSRTLKTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDT 281
            .|...:.:|:. |.|.|...:.::...|..  ....|.::..|...:..|     .:.::.||..
Mouse   217 DPFLLSVVLFPFLTPIYEMLNLSIFPRQSM--NFFKKFVKKMKKDRLDYN-----QKNRVDFLQL 274

  Fly   282 LLSSTIDGRPLNSK-----------ELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFK 335
            ::::.      |||           |:..:...|:|.|:|.|::.:||.:|.|:.|.|.|:||..
Mouse   275 MMNTQ------NSKGQESLKALSDLEMAAQTLIFIFGGYDGTSTSISFIMYELATHPDVQKKLQD 333

  Fly   336 EQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLN 400
            |....:.|.   ...|:..:..|:|||:.:.|:.|:||.|..|.||::||..|.|..:||||.:.
Mouse   334 EIDRALPNK---APVTYDALMDMEYLDMVVNESLRLYPVVSRIDRFSKKDVEIHGVFIPKGTIVM 395

  Fly   401 LGLVMLGYNEKVFKDPHKFRPERFELEKPG---PFEYVPFSAGPRNCIGQKFALLEIKTVVSKII 462
            :.:..|..:.:.:.:|..|.||||..|..|   |:.|:||..|||||||.:|||:.:|..|:.::
Mouse   396 IPIYPLHRDPEYWPEPEDFCPERFSKENKGNIDPYIYMPFGNGPRNCIGMRFALISVKLAVTGVL 460

  Fly   463 RNFEVLP 469
            :||.|.|
Mouse   461 QNFTVQP 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	118/460 (26%)
Cyp3a57	NP_001093650.1	p450	39..493	CDD:278495	119/462 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820