DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e2 and Cyp3a25

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_062766.2	Gene:	Cyp3a25 / 56388	MGIID:	1930638	Length:	503	Species:	Mus musculus

Alignment Length:	542	Identity:	129/542 - (23%)
Similarity:	243/542 - (44%)	Gaps:	90/542 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WFVLYIFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSW---- 62
            |.:|...|.|..:...|.. ..|::..:    .||:.|||:|              |:|::
Mouse    12 WVLLVTSLVLFYIYGTYSH-GLFKKLGI----PGPKPLPLLG--------------TIFNYYDGM 57

  Fly    63 -------WHQYGKDNFVFWIGTYSNVLVTSSKYLEFILSSQ--TLITKSDIYQLTHP--WLGLGL 116
                   :.:||| .:.|:.|....:.:...:.::.:|..:  ::.|....:   .|  ::...:
Mouse    58 WKFDEDCYKKYGK-IWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRFF---GPVGFMKKAI 118

  Fly   117 LTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDV 181
            ..|...:|.:.|.:::|.|....|::...:|.:.....:::|:...........::.....::||
Mouse   119 TISEDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPISMKDIFGAYSMDV 183

  Fly   182 ICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYR-LAPDYPAYSRTL--KTL 243
            |..|:.||:::::.|.....||..|.:   :..:.|.|...:.:|:. |.|.|...:.::  :..
Mouse   184 ITGTSFGVNVDSLNNPQDPFVQKAKKI---LKFKIFDPFLLSIILFPFLTPIYEMLNFSIFPRDS 245

  Fly   244 QDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTIDGRPLNSK-----------EL 297
            .:|..:.: ||::..:..:...|..|        ||..::::.      |||           |:
Mouse   246 MNFFKKFV-KRMKKERLASNQKNRVD--------FLQLMMNTQ------NSKGQESQKALSDLEM 295

  Fly   298 YEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLD 362
            ..:...|:|.|:|.|::.:|..:|.|:.|.|.|:||..|....:.|.   ...|:..:..|:|||
Mouse   296 AAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNK---APVTYDALMDMEYLD 357

  Fly   363 LFIKEAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELE 427
            :.:.|:.|:||....:.|.::||..|:|..:||||.:.:.:..|..|.:.:.:|.:|.||||..|
Mouse   358 MVVNESLRLYPIAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKE 422

  Fly   428 KPG---PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPD 489
            ..|   |:.|:||..|||||||.:|||:.||..|..:::||.|.|..:          |.|.|
Mouse   423 NKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEE----------TQIPL-- 475

  Fly   490 AERKKRDPYRHKYDPILSAVLT 511
              :..|:|......||:..|::
Mouse   476 --KISREPIFQPEKPIILKVVS 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	114/465 (25%)
Cyp3a25	NP_062766.2	p450	39..493	CDD:278495	122/506 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810