DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e2 and Cyp4f1

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_062569.2	Gene:	Cyp4f1 / 56266	RGDID:	70926	Length:	524	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	162/553 - (29%)
Similarity:	270/553 - (48%)	Gaps:	85/553 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WFVLYIF----LALPLLLVAYLELSTFRRRRVLNKFNGPRGLP-------LMGNAHQMGKNPSE- 54
            |..|.:|    :...:|...|.....|||.         ||.|       |||:...:  .|:|
  Rat    19 WQTLLLFGASWILAQILTQIYAAYRNFRRL---------RGFPQPPKRNWLMGHVGMV--TPTEQ 72

  Fly    55 ---ILDTVFSWWHQYGKDNFVFWIGTYSNVL-VTSSKYLEFILSSQTLITKSDI--YQLTHPWLG 113
               .|..:...:.|    .|:.|||....|: :..|..:..||::...:...|:  |.:..||||
  Rat    73 GLKELTRLVGTYPQ----GFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDVIFYTILKPWLG 133

  Fly   114 LGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLK---TVAAGDNIFDFQEQAH 175
            .|||.|.|.||.:||:|:|||||||||:.:.::.|:::.  |.|.|   .::.|.:..|..|...
  Rat   134 DGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTN--IMHAKWKRLISEGSSRLDMFEHVS 196

  Fly   176 YLTLDVICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTL 240
            .:|||.:.........|..| :||..:.|..::...:..|...||...:|||.|.||...:.:..
  Rat   197 LMTLDSLQKCVFSFDSNCQE-KSSEYIAAILELSALVAKRHQQPLLFMDLLYNLTPDGMRFHKAC 260

  Fly   241 KTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKK-----MAFLDT-LLSSTIDGRPLNSKELYE 299
            ..:.:||:.:|.:|     ...:.....|||.:.|     :.|:|. ||:...||:.|:.:::..
  Rat   261 NLVHEFTDAVIRER-----RRTLPDQGLDEFLKSKAKSKTLDFIDVLLLTKDEDGKELSDEDIRA 320

  Fly   300 EVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLF 364
            |..||||||||||.||:|:.:|.|::|.:.|.:..:|.:|::.:.: ..:..:.:::|:.:|.:.
  Rat   321 EADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQELLRDRD-PEEIEWDDLAQLPFLTMC 384

  Fly   365 IKEAQRVYPSVPFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFE--- 425
            |||:.|::|.|..|.|...:|.:: ||..:|||....:.:..:.:|..|:.||..:.|.||:
  Rat   385 IKESLRLHPPVTVISRCCTQDILLPDGRTIPKGIICLISIFGIHHNPSVWPDPEVYNPFRFDPEN 449

  Fly   426 LEKPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDA 490
            ::...|..::||||||||||||.||:.|:|..::..:..|.:                   |||.
  Rat   450 IKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRL-------------------LPDD 495

  Fly   491 ERKKRDPYRHKYDPILSAVLTLKSENGLYIRLK 523
            :..:|.|           .|.|::|.||::|::
  Rat   496 KEPRRQP-----------ELILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	143/460 (31%)
Cyp4f1	NP_062569.2	CYP4F	74..515	CDD:410772	145/483 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348638
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650