DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and cyp4v8

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001071070.1	Gene:	cyp4v8 / 558851	ZFINID:	ZDB-GENE-061103-601	Length:	513	Species:	Danio rerio

Alignment Length:	531	Identity:	188/531 - (35%)
Similarity:	280/531 - (52%)	Gaps:	43/531 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YIFLALPLLLVAYLELSTFRRRRVLNKFNGPRGL-------PLMGNAHQMGKNPSEILDTVFSWW 63
            |.|:|..:.::.:..::....:..|:|:...:.:       |.:|||.|...|....|..|....
Zfish    10 YGFVAASVCVICFAYITYQLLKSYLHKWKELKPIPGIGNTFPFIGNALQFKSNGDFFLQLVGYTT 74

  Fly    64 HQYGKDNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLTSTGSKWHKHR 128
            ..........|||....:::..::.:|.:|::...|.|:..||..|||||.|||||||.||.:.|
Zfish    75 EFQNSPLLKIWIGPIPFLILFHAETVETVLNNPVHIDKAYAYQFLHPWLGTGLLTSTGDKWRRRR 139

  Fly   129 KMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMGVSINA 193
            ||:||.|||:||.:|.|||||.:...|:.|:. .||...|:.........||:||:||||..|.|
Zfish   140 KMLTPTFHFSILTEFLEVMNEQAEVLIEKLEK-QAGKGPFNCFSHITLCALDIICETAMGKRIYA 203

  Fly   194 MENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAKRIEAH 258
            ..|..|..|:....|...|..|...|....:.:|....:...::|:||.|..||..:|.:|.| :
Zfish   204 QSNYDSEYVRTVYRMSDIITRRQRMPWYWPDFVYNYVGEGREHNRSLKILHSFTESVINERAE-Y 267

  Fly   259 KSGAVSTNAGDEFTRKKMAFLDTLL-SSTIDGRPLNSKELYEEVSTFMFEGHDTTTSGVSFAVYL 322
            .|...|.:..|:..||:.||||.|| :...||:.|..|::.|||.||||||||||.:.:::|::|
Zfish   268 LSYVESDSESDQGMRKRRAFLDMLLKTKDEDGKMLTHKDIQEEVDTFMFEGHDTTAAAMNWAIHL 332

  Fly   323 LSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYV 387
            |..|.:.|||..:|..||.|.||  |....:::.:::||:..|||:.|::|||||..|....|..
Zfish   333 LGSHPEVQRKAQQELFEVFGESE--RPVNTEDLKKLRYLECVIKESLRLFPSVPFFARTICDDTQ 395

  Fly   388 IDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEK---PGPFEYVPFSAGPRNCIGQKF 449
            |:|..|||||.:.:....|..:.:.|.||.:||||||..|.   ..|:.|:|||||.||||||:|
Zfish   396 INGFKVPKGTNIVVITYALHRDPRFFPDPEEFRPERFLPENCVGRHPYAYIPFSAGLRNCIGQRF 460

  Fly   450 ALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDPILSAVLTLKS 514
            |::|.|.:::.|:|.|.::..                      :||:..|    |:  ..|.|:.
Zfish   461 AIMEEKVILAYILRYFNIVAC----------------------QKREELR----PL--GELVLRP 497

  Fly   515 ENGLYIRLKER 525
            |.|::|.|:.|
Zfish   498 EQGIWITLERR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	172/444 (39%)
cyp4v8	NP_001071070.1	p450	44..501	CDD:278495	179/488 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589836
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.750