DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and Cyp2c67

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001019890.1	Gene:	Cyp2c67 / 545288	MGIID:	3612288	Length:	491	Species:	Mus musculus

Alignment Length:	524	Identity:	123/524 - (23%)
Similarity:	201/524 - (38%)	Gaps:	123/524 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLALPLLLVAYLELSTFRRRRVL-NKFNGPRGLPLMGNAHQMG-KNPSEILDTVFSWWHQYGKDN 70
            |:.|.|.|...|.||.:|:|... |...||..||::||.|.:. |:..:.| |.||  ..|| ..
Mouse     4 FVVLVLCLSFLLVLSLWRQRSARGNLPPGPTPLPIIGNYHLIDMKDIGQCL-TNFS--KTYG-PV 64

  Fly    71 FVFWIGTYSNVLVTSSKYLE--FILSSQTL-----------ITKSDIYQLTHPWLGLGLLTSTGS 122
            |..:.|:...|::...:.::  ||...:..           :||           |.|:..|.|:
Mouse    65 FTLYFGSQPIVVLHGYEAMKEAFIDHGEEFSGRGRFPFFDKVTK-----------GKGIGFSHGN 118

  Fly   123 KWHKHRKMITPAFHFNILQD-------FHEVMNENSTKFIKHLKTV------------AAGDNI- 167
            .|     ..|..|..|.|::       ....:.|.:...:|.||..            .|..|:
Mouse   119 VW-----KATRVFTINTLRNLGMGKRTIENKVQEEAQWLMKELKKTNGLPCDPQFIIGCAPCNVI 178

  Fly   168 --FDFQEQAHYLTLDVICDTAMGVSINAMENRSSSIVQAFK------DMCYNINMRAFHPLKRNE 224
              ..||.:..|...|.:  :.:|......|..||...|.|.      |.|         |.:.|:
Mouse   179 CSIVFQNRFDYKDKDFL--SLIGKVNECTEILSSPGCQIFNAVPILIDYC---------PGRHNK 232

  Fly   225 LLYRLAPDYPAYSRTLKTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTIDG 289
            ....               ..:....:.::|:.|:.....||..|        |:|..|......
Mouse   233 FFKN---------------HTWIKSYLLEKIKEHEESLDVTNPRD--------FIDYFLIQRCQE 274

  Fly   290 RPLNSKELYEE-----VSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRD 349
            :.:...|...|     |:..:|.|.::.:|.:.||:.||.:|.....|:.:|...|:|..   |.
Mouse   275 KGIEHMEYTIEHLATLVTDLVFGGTESLSSTMRFALLLLMKHTHITAKVQEEIDNVIGRH---RS 336

  Fly   350 ATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTE-------KDYVIDGDLVPKGTTLNLGLVMLG 407
            ...|:.:.|.|.:..:.|.|| |..:..|....|       ::|     .:||||.:...|..:.
Mouse   337 PCMQDRNHMPYTNAMVHEVQR-YVDLGPISLVHEVTCDTKFRNY-----FIPKGTQVMTSLTSVL 395

  Fly   408 YNEKVFKDPHKFRPERFELEKPGPFE----YVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVL 468
            ::...|.:|..|.|..| |:..|.|:    :||||||.|.|:|:..|.:|:...::.|::||::.
Mouse   396 HDSTEFPNPEVFDPGHF-LDDNGNFKKSDYFVPFSAGKRICVGESLARMELFLFLTTILQNFKLK 459

  Fly   469 PALD 472
            |.:|
Mouse   460 PLVD 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	111/491 (23%)
Cyp2c67	NP_001019890.1	p450	30..487	CDD:278495	113/498 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010