Protein Alignment Cyp4e2 and Cyp4a1

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_787031.1
• Gene: Cyp4a1 / 50549
• RGDID: 68945
• Length: 509
• Species: Rattus norvegicus
• Alignment Length: 543
• Identity: 167/543 - (30%)
• Similarity: 267/543 - (49%)
• Gaps: 83/543 - (15%)

  Fly     9 LALPLLLVAYLELSTFRR--RRVLNKFNGPRGLPLMGNAHQMG-KNPSEILDTV------FSWWH 64
            |.|.||||..::....|:  .:...:|..|......|:....| |...:|:..|      |..|
  Rat    25 LGLLLLLVKAVQFYLQRQWLLKAFQQFPSPPFHWFFGHKQFQGDKELQQIMTCVENFPSAFPRW- 88

  Fly    65 QYGKDNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSD-----IYQLTHPWLGLGLLTSTGSKW 124
                    || |:.:.::|....|::.||.      :||     :|:|..||:|.|||...|..|
  Rat    89 --------FW-GSKAYLIVYDPDYMKVILG------RSDPKANGVYRLLAPWIGYGLLLLNGQPW 138

  Fly   125 HKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVI--CDTAM 187
            .:||:|:|||||::||:.:.:.|.::....:...:.:|..|:..:..:....:|||.:  |..:.
  Rat   139 FQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWEQLAGQDSSIEIFQHISLMTLDTVMKCAFSH 203

  Fly   188 GVSINAMENRSSSIVQA---FKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNE 249
            ..|:. ::....|.:||   ..|:.::.....||   :|:.:|..:.:...::|..:...|.|:.
  Rat   204 NGSVQ-VDGNYKSYIQAIGNLNDLFHSRVRNIFH---QNDTIYNFSSNGHLFNRACQLAHDHTDG 264

  Fly   250 IIAKRIEAHKSGAVSTNAGD-EFTRKK--MAFLDTLLSSTID-GRPLNSKELYEEVSTFMFEGHD 310
            :|..|.:..:      |||: |..:||  :.|||.||.:.:: |..|:.|:|..||.||||||||
  Rat   265 VIKLRKDQLQ------NAGELEKVKKKRRLDFLDILLLARMENGDSLSDKDLRAEVDTFMFEGHD 323

  Fly   311 TTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSV 375
            ||.||||:..|.|:.|.:.|::..:|.:.|:|:   |...|:..:.|:.|..:.||||.|:||.|
  Rat   324 TTASGVSWIFYALATHPEHQQRCREEVQSVLGD---GSSITWDHLDQIPYTTMCIKEALRLYPPV 385

  Fly   376 PFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKP-GPFEYVPFS 438
            |.|.|........ ||..:|||..:.|.:..|.:|.||:.:|..|.|.||..:.| ....::|||
  Rat   386 PGIVRELSTSVTFPDGRSLPKGIQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSPRHSHSFLPFS 450

  Fly   439 AGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYD 503
            .|.|||||::||:.|:|.:|:..:..||:||                          ||.:   .
  Rat   451 GGARNCIGKQFAMSEMKVIVALTLLRFELLP--------------------------DPTK---V 486

  Fly   504 PILSAVLTLKSENGLYIRLKERH 526
            ||....|.|||:||:|:.||:.|
  Rat   487 PIPLPRLVLKSKNGIYLYLKKLH 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	147/467 (31%)
Cyp4a1	NP_787031.1	CYP4B-like	71..504	CDD:410771	152/490 (31%)