DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e2 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	XP_038935701.1	Gene:	Cyp4f40 / 503122	RGDID:	1559596	Length:	530	Species:	Rattus norvegicus

Alignment Length:	575	Identity:	163/575 - (28%)
Similarity:	269/575 - (46%)	Gaps:	111/575 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WFVLYIFLALPLLLVAYLELSTFRRR-------------RVLNKFNGPRGLPLMGNAHQMGKNP- 52
            |..|....|.|.||::.:.:|.|..|             |:......|:.....|:   :|.:|
  Rat     8 WLGLGPMSASPWLLLSLVGVSWFLTRCLTQIYTLYAKCQRLCGFPQPPKRSWFWGH---LGMSPP 69

  Fly    53 -----SEILDTVFSWWHQYGKDNFVFWIGTYSNVL-VTSSKYLEFILSSQTLITKSD--IYQLTH 109
                 .::.:.|.::     ...|:.|:|....:: :.....:..:||:...:...|  .|....
  Rat    70 TEEGMKQMTELVATY-----PQGFMTWLGPIVPLITLCHPDIIRSVLSASAAVAPKDGIFYSFLK 129

  Fly   110 PWLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFI--KHLKTVAAGDNIFDFQE 172
            ||||.|||.|...||.:||.|:|||||||||:.:.::.|: ||..:  |.|:..:.|....|..|
  Rat   130 PWLGDGLLVSASDKWSRHRSMLTPAFHFNILKPYVKIFND-STNIMHAKWLRLASGGSAHLDMFE 193

  Fly   173 QAHYLTLDVICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNE-------LLYRLA 230
            ....:|||.:.......:.|..| :.|..:.|..::...:       :||||       |||||.
  Rat   194 NISLMTLDTLQKCVFSFNSNCQE-KPSEYIAAILELSALV-------VKRNEQLLLHMDLLYRLT 250

  Fly   231 PDYPAYSRTLKTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTR-----KKMAFLDT-LLSSTIDG 289
            ||...:.:....:.|||..:|.:|     ...:..:.||:..:     |.:.|:|. |||...||
  Rat   251 PDGRRFYKACHLVHDFTYAVIQER-----RRTLPKHGGDDVIKAKAKSKTLDFIDVLLLSKDEDG 310

  Fly   290 RPLNSKELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQE 354
            :.|:.:::..|..||||||||||.||:|:.:|.|::|.:.|.:..:|.:|::      ||...:|
  Rat   311 KELSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQELL------RDRDSEE 369

  Fly   355 I------------SQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVI-DGDLVPKGTTLNLGLVML 406
            |            :|:.:|.:.|||:.|::|.|..:.|...:|..: ||.::|||....:.:...
  Rat   370 IECSCGVLLRDDLAQLPFLTMCIKESLRLHPPVTMVSRCCTQDISLPDGRVIPKGIICIINIFAT 434

  Fly   407 GYNEKVFKDPHKFRPERFE---LEKPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVL 468
            .:|..|::||..:.|.||:   ::...|..::||||||||||||.||:.|:|..|:..:..|.|
  Rat   435 HHNPTVWQDPEVYDPFRFDPENIQARSPLAFIPFSAGPRNCIGQTFAMNEMKVAVALTLLRFRV- 498

  Fly   469 PALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDPILSAVLTLKSENGLYIRLK 523
                              |||.:..:|.|           .|.|::|:||::|::
  Rat   499 ------------------LPDDKEPRRKP-----------ELILRAEDGLWLRVE 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	142/473 (30%)
Cyp4f40	XP_038935701.1	CYP4F	74..522	CDD:410772	148/502 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348637
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650