DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	493	Identity:	113/493 - (22%)
Similarity:	220/493 - (44%)	Gaps:	60/493 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WFVLYIFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQY 66
            |.::::.:.| |.:........|::..:    .|||..|..|......|.   ..:.......:|
Zfish    11 WTLVFLVITL-LYMYGVWPHGFFKKLGI----PGPRPWPFFGTFLSYTKG---FFNFDMECAKKY 67

  Fly    67 GKDNFVFWIGTYSN----VLVTSSKYLEFILSSQ---TLITKSDI-YQLTHPWLGLGLLTSTGSK 123
            ||    .| |.|..    ::||..:.::.|:..:   |...:.:: ..|..| |..|:......:
Zfish    68 GK----VW-GIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREVNVDLAGP-LADGISAVKDER 126

  Fly   124 WHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMG 188
            |.:.|..::|.|....|::...:...::.:|||:::. ...:.....:|.....:|||:..::..
Zfish   127 WKRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQK-RDHEQPVKIKEVVAPYSLDVVTSSSFS 190

  Fly   189 VSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTL---------KTLQ 244
            |.|:::.|.....|...|:.   :....|.||    :|:...  :|:.:..|         :::.
Zfish   191 VDIDSINNPDDPFVTNIKNF---LKFSLFSPL----ILFLTL--FPSIANLLGKMGISVFSRSIM 246

  Fly   245 DFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKM-------AFLDTLLSSTIDGRPLNSKELYEEVS 302
            :|....:.|..:.||    .:|...:|.|..:       ...||.....:.|  |...|:..:..
Zfish   247 NFFYTALRKIKDEHK----DSNGRVDFLRLMIQNQIPDDQAKDTTSEQPVKG--LTDHEILSQSF 305

  Fly   303 TFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKE 367
            .|:..|::||::.:||.::.|:.:.|...||.:   |:..|..|....::..:.:|.||::.|.|
Zfish   306 IFILGGYETTSTTLSFLLHNLATNPDCLEKLVE---EIDKNFPLDTPISYDALMKMDYLEMSINE 367

  Fly   368 AQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKPGPF 432
            :.|:.|:.|.:.|..:|...::|..:||.|.:.:...:|..:.:::..|.:||||||..|....|
Zfish   368 SMRLLPTAPRLERVCKKTVELNGITIPKDTLVAIPTYVLNRDPQLWDSPQEFRPERFSPENKSEF 432

  Fly   433 ---EYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEV 467
               .::||..|||||||.:|||:.:|.:|.|:::||.:
Zfish   433 LQYAFMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSL 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	109/460 (24%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	109/461 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810