Protein Alignment Cyp4e2 and cyp-25A3

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001040850.1
• Gene: cyp-25A3 / 4363046
• WormBaseID: WBGene00014697
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 545
• Identity: 151/545 - (27%)
• Similarity: 242/545 - (44%)
• Gaps: 81/545 - (14%)

  Fly     8 FLALPLLLVA------YLELSTFRRRRVLNK--FNGPRGLPLMGNAHQMGKNPSEI-LDTVFSWW 63
            ||.|..:||:      |:.|:...|.|:..|  .:||....||||..|:.:..::: .|..:.|:
 Worm     3 FLILTSILVSLVSFIIYVILARKERFRLRGKIGLSGPEPHWLMGNLKQIIERKAKLGYDDSYDWY 67

  Fly    64 H----QYGKDNFVFWIGTYSNVLVTSSKYLE--FILSSQTLITKSDIYQLTHPWLGLGLLTST-G 121
            :    |:| :.|..:.||..|:.:|:.:.::  ||.:......::....:....|...||.:| .
 Worm    68 NKLHKQFG-ETFGIYFGTQLNINITNEEDIKEVFIKNFSNFSDRTPPPIIEDNKLKESLLQNTYE 131

  Fly   122 SKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTA 186
            |.|...|..|.|.|....::..||.::.....|::.||..|:....:|..:....||||||...|
 Worm   132 SGWKHTRSAIAPIFSTGKMKAMHETIHSKVDLFLEILKEKASSGQKWDIYDDFQGLTLDVIGKCA 196

  Fly   187 MGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTN--- 248
            ..:..|...:|:.......:....||::|....:..:.|       :|..|:..|.|..||:
 Worm   197 FAIDSNCQRDRNDVFYVNARKFITNIDIRHSKIISTSFL-------FPELSKLWKVLYRFTDLAK 254

  Fly   249 ------EIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTID-GRPLNSKELYEEVSTFMF 306
                  |.:|...|..:.|..|.:         :..|..||:...| .:|:..:|:.|....|:.
 Worm   255 AEIPLVEGLADVYERRRGGEGSDS---------VDLLKLLLNREDDKSKPMTKQEVIENCFAFLL 310

  Fly   307 EGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRV 371
            .|::||::.:::..||||::.:.|:||::|..|...|..|    |:..|..|||||...||..|.
 Worm   311 AGYETTSTAMTYCSYLLSKYPNVQQKLYEEIMEAKENGGL----TYDSIHNMKYLDYVYKETLRC 371

  Fly   372 YPSV-PFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGY----NEKVFKDPHKFRPERFE--LEKP 429
            ||.| .|..|...||..|.|...|||..    :|.|.:    |.:.:..|.:|.|||||  .||.
 Worm   372 YPPVIHFSNRRCLKDITIRGQFYPKGAI----VVCLPHTVHRNPENWDSPEEFHPERFENWEEKS 432

  Fly   430 GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAE--- 491
            ...:::||..|||.|:|.:||.:|.||.::|::..|       ||...:|....   :||..
 Worm   433 SSLKWIPFGVGPRYCVGMRFAEMEFKTTIAKLLDTF-------ELKQFEGEADL---IPDCNGVI 487

  Fly   492 RKKRDPYRHKYDPILSAVLTLKSEN 516
            .:.:||.|          |.||..|
 Worm   488 MRPKDPVR----------LHLKPRN 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	130/472 (28%)
cyp-25A3	NP_001040850.1	CYP3A-like	73..495	CDD:410678	127/456 (28%)