DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and Cyp6a18

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	122/540 - (22%)
Similarity:	235/540 - (43%)	Gaps:	102/540 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WFVLYIFLALPLLLVAYL---ELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWW 63
            :|:..:.:|| |.:|.|:   :|:.|:||.:  .::.|.  ||.||..  |...:..:..:...:
  Fly     5 YFLFQVAVAL-LAIVTYILHRKLTYFKRRGI--PYDKPH--PLRGNME--GYKKTRTVHEIHQEY 62

  Fly    64 HQYGKDNFVFWIGTYSNVLVTSSKYLEFI----LSSQTLI------TKSDIY--QLTHPWLGLGL 116
            :...:::...::|.|     ...|...|:    |:.|.||      |...||  :...| :...|
  Fly    63 YNKYRNSKAPFVGFY-----LFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNEKDDP-MSAHL 121

  Fly   117 LTSTGSKWHKHRKMITPAFH-----------FNILQDF----HEVMNENSTKFIKHLKTVAAGDN 166
            ....|.:|...|..::..|.           .::.::|    ||.::|||
  Fly   122 FNLDGPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENS--------------- 171

  Fly   167 IFDFQEQAHYLTLDVICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAP 231
            |.|.::.....|:|||...|.|:..|::.:..:..:        :...||....:...|:..|..
  Fly   172 ILDVRDLVARFTVDVIGTCAFGIKCNSLRDEKAEFL--------HFGRRALLDSRHGNLVSGLMR 228

  Fly   232 DYPAYSRTL------KTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLL------S 284
            .||..:|.|      ..:|:|...|:.:.:...:...:          |:..|:|.|:      :
  Fly   229 SYPNLARRLGLCRNTAQIQEFYQRIVKETVTLREKENI----------KRNDFMDMLIGLKNQKN 283

  Fly   285 STIDG----RPLNSKELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSE 345
            .|::.    :.|...|:..:...|...|.||::|.:.||:|.|:::...|.|:..|..:|:...:
  Fly   284 MTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHD 348

  Fly   346 LGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVIDGD---LVPKGTTLNLGLVMLG 407
              :..|::.|..:||||..|.|..|.|..||.:.|...|.:|:.|:   ::..|.::.:....:.
  Fly   349 --QKFTYECIKDLKYLDQVINETLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIH 411

  Fly   408 YNEKVFKDPHKFRPERF---ELEKPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLP 469
            ::..::.:|::||||||   |..|.....::||..|||||||.:|..::.:..::.:|:||...|
  Fly   412 HDPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSP 476

  Fly   470 --ALDELVSKDGYISTTIGL 487
              |..:.::.|.:.:..:|:
  Fly   477 CSATPDPLTFDPHSAILLGI 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	108/482 (22%)
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	112/504 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810