Protein Alignment Cyp4e2 and Cyp12a4

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Alignment Length: 571
• Identity: 123/571 - (21%)
• Similarity: 231/571 - (40%)
• Gaps: 150/571 - (26%)

  Fly     2 WFVLYIFLALPLLLVAYLEL------STFRRRRVLNKFNGPRG-------LP-LMGNAHQMGKNP 52
            |.....|..:|.|.:..|.:      ..::...::..|...|.       :| :|||...:..:.
  Fly    41 WLQAKPFEQIPRLNMWALSMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHN 105

  Fly    53 SEILDTVFSWWHQYGKDNFVFW---IGTYSNVLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGL 114
            .:..:.||.        |...|   .|.|: :|....:|            :.|.||..     :
  Fly   106 PQDFEVVFR--------NEGVWPNRPGNYT-LLYHREEY------------RKDFYQGV-----M 144

  Fly   115 GLLTSTGSKWHKHRKMITPAFHFNILQD-----FHEVMNENSTKFIKHL------KTVAAGDNIF 168
            |::.:.|..|...|.::.|.    ::|.     :::.|::.:.:|::.:      .|:.|.|
  Fly   145 GVIPTQGKPWGDFRTVVNPV----LMQPKNVRLYYKKMSQVNQEFVQRILELRDPDTLEAPD--- 202

  Fly   169 DFQEQAHYLTLDVICDTAMGVSINAMENRSSSIVQAFKDMCY-------NINMRAFHPLKRNELL 226
            ||.:..:..||:.:...|:...:..::| |:...:|.|...|       :|::.    :|.:...
  Fly   203 DFIDTINRWTLESVSVVALDKQLGLLKN-SNKESEALKLFHYLDEFFIVSIDLE----MKPSPWR 262

  Fly   227 YRLAPDYPAYSRTLKTLQDFT----NEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTI 287
            |...|......|.|..:|:.|    :|.|.:..:..|.|.|
  Fly   263 YIKTPKLKRLMRALDGIQEVTLAYVDEAIERLDKEAKEGVV------------------------ 303

  Fly   288 DGRPLNSKELYE-------EVSTFM-----FEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREV 340
              ||.|.:.:.|       :|:|.|     ..|.|||:|..:..:..|:::.::|.:|.:|..:|
  Fly   304 --RPENEQSVLEKLLKVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKV 366

  Fly   341 MGNSELGRDATFQEIS--QMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGL 403
            :.|    :::.|.|.|  .:.||...|||:||::|.:....|...:|.|:.|..||.||.:|:..
  Fly   367 LPN----KNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVP 427

  Fly   404 VMLGYNEKVFKDPHKFRPERF--------------ELEKPGPFEYVPFSAGPRNCIGQKFALLEI 454
            :.....::.|....:|.|||:              ||:...||.::||..|||.|:|::...:|:
  Fly   428 LNALTRDEYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMEL 492

  Fly   455 KTVVSKIIRNFEV---LPALDELVSKDGYISTTIGLPDAERKKRDPYRHKY 502
            :...:::||||.|   .|      :::.:.|..|.||:.      |.:.|:
  Fly   493 ELGTARLIRNFNVEFNYP------TENAFRSALINLPNI------PLKFKF 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	110/491 (22%)
Cyp12a4	NP_650783.2	CYP24A1-like	82..528	CDD:410677	116/525 (22%)