DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and Cyp313a1

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	123/506 - (24%)
Similarity:	228/506 - (45%)	Gaps:	42/506 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQYGKDNF 71
            :.||:..|...|...|..|...::.|..||.|||::|::.:........|.....:.::|| ...
  Fly     6 LLLAVGALFWIYFLWSRRRLYFLMLKIPGPIGLPILGSSLENIITYKRKLSFRTKYLNKYG-STI 69

  Fly    72 VFWIGTYSNVLVTSSKYLEFILSSQTLITKSD-IYQLTHPWLGLGLLTSTGSKWHKHRKMITPAF 135
            :.|:|....::....|.:|.|.||.....||. |.......:|.|||......|...||...|:|
  Fly    70 LTWMGPVPFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITSCMGNGLLGKQDPHWLDRRKHFNPSF 134

  Fly   136 HFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMGVSINAMEN-RSS 199
            ..::|..|..:. :..||.:.:|..........|...:....:..:...|.||..:...|: ::.
  Fly   135 KQDLLLSFFHIF-DAETKVLMNLLDTYVDKGEIDVVPEMLRWSFKIAAQTTMGSEVKHDEHFKNG 198

  Fly   200 SIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPA-----YSRTLKTLQDFTNEII---AKRIE 256
            |:|::|:.:..:..:....||.:|.::.::. .|..     :||..|.|.:..|:.:   .|...
  Fly   199 SLVESFESLISHSTLNILMPLVQNRMISKIC-GYDKLRADNFSRIQKMLDNVVNKKVNPLPKTDS 262

  Fly   257 AHKSGAVSTNAGDEFTRKKMAFLDTLLSSTIDGRPLNSKELYEEVSTFMFEGHDTTTSGVSFAVY 321
            ..:|..|...|.:.:.:..:.::|                :..|....:..|:||:...|..|::
  Fly   263 DPESNIVINRAMELYRKGDITYMD----------------VKSECCIMIAAGYDTSALTVYHALF 311

  Fly   322 LLSRHQDEQRKLFKEQREVMGNS-ELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKD 385
            ||:.|.:.|..:|:|...|..:: ..|  .|:.::.::.||:..|||..|:.|::|...|.|:.|
  Fly   312 LLANHPEHQEAVFEELNGVFPDAGHFG--ITYPDMQKLDYLERVIKETLRLIPAIPITARETKND 374

  Fly   386 Y-VIDGDLVPKGTTLNLGLVMLGYNEKVF-KDPHKFRPERF---ELEKPGPFEYVPFSAGPRNCI 445
            . :.:|.|:|||..:.:.:.....|.:|: .|...|.|:.|   .:|:..|:.|:||:.|.||||
  Fly   375 VRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNFLAENMEQKHPYAYIPFARGKRNCI 439

  Fly   446 GQKFALLEIKTVVSKIIRNFEVLPA--LDELVSKDGYISTTIGLPDAERKK 494
            |.|:|::..|..:.:|:||:::..:  ..:||..|   :.|:.|.:..|.|
  Fly   440 GSKYAMMSSKFALCRILRNYKISTSTLYKDLVYVD---NMTMKLAEYPRLK 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	109/449 (24%)
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	109/450 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	5	4.860