Protein Alignment Cyp4e2 and CYP4F3

DIOPT Version :9

• Sequence 1: NP_001286196.1
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Alignment Length: 471
• Identity: 147/471 - (31%)
• Similarity: 241/471 - (51%)
• Gaps: 55/471 - (11%)

  Fly    69 DNFVFWIGTYSNVL-VTSSKYLEFILSSQTLITKSD--IYQLTHPWLGLGLLTSTGSKWHKHRKM 130
            |...:|:|.:..:: :....|::.:|.:...|...|  .|....||||.|||.|.|.||.:||:|
Human    86 DMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHRRM 150

  Fly   131 ITPAFHFNILQDFHEVMNENSTKFIKHLK---TVAAGDNIFDFQEQAHYLTLDVICDTAMGVSIN 192
            :|||||||||:.:.::.||:..  |.|.|   ..:.|....|..|....:|||.:.........:
Human   151 LTPAFHFNILKPYMKIFNESVN--IMHAKWQLLASEGSARLDMFEHISLMTLDSLQKCVFSFDSH 213

  Fly   193 AMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAKRIEA 257
            ..| :.|..:.|..::...:..|....|...:.||.|.||...:.|..:.:.|||:.:|.:|...
Human   214 CQE-KPSEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRT 277

  Fly   258 HKSGAVSTNAGDEFTR-----KKMAFLDT-LLSSTIDGRPLNSKELYEEVSTFMFEGHDTTTSGV 316
            ..|..|     |:|.:     |.:.|:|. |||...||:.|:.:::..|..||||||||||.||:
Human   278 LPSQGV-----DDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGL 337

  Fly   317 SFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRF 381
            |:.:|.|::|.:.|.:..:|.:|::.:.| .::..:.:::|:.:|.:.|||:.|::|.||.:.|.
Human   338 SWVLYHLAKHPEYQERCRQEVQELLKDRE-PKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRC 401

  Fly   382 TEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFE---LEKPGPFEYVPFSAGPR 442
            ..:|.|: ||.::|||....:.:....:|..|:.||..:.|.||:   :::..|..::|||||||
Human   402 CTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPR 466

  Fly   443 NCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDPILS 507
            |||||.||:.|:|.|:...:..|.|                   |||....:|.|
Human   467 NCIGQAFAMAEMKVVLGLTLLRFRV-------------------LPDHTEPRRKP---------- 502

  Fly   508 AVLTLKSENGLYIRLK 523
             .|.|::|.||::|::
Human   503 -ELVLRAEGGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	136/415 (33%)
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	146/467 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154791
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650