DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and Cyp312a1

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	480	Identity:	146/480 - (30%)
Similarity:	255/480 - (53%)	Gaps:	28/480 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLALPLLLVA---YLELSTFRRR----RVLNKFNGPRGLPLMGNAHQMGK--NPSEI---LDTVF 60
            :|...|||:|   || |..|.|:    |:.:|:..|..||.:|:.|.:.|  .|..:   .:.:.
  Fly     3 WLGFGLLLLALSLYL-LYVFERQSRIDRLTHKWPAPPALPFIGHLHILAKLVGPHPLRRATEMIN 66

  Fly    61 SWWHQYGKDNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLTSTGSKWH 125
            ...|.:   ....|:||...::..:.|.::.:.|:|.|:.|::.|::...||..||.||...||.
  Fly    67 EHLHDH---RAKLWMGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLFTSGFEKWS 128

  Fly   126 KHRKMITPAFHFNILQDFHEVMNENSTKFIKHL-KTVAAGDNIFDFQEQAHYLTLDVICDTAMGV 189
            ..||::.|||::.:::.|..|..:.|...:.:: |...:||.| ||.:.....|||.||:||:||
  Fly   129 HRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQI-DFLQLISCFTLDTICETALGV 192

  Fly   190 SINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAKR 254
            |:.:..:..|..:.|.|.:...|:.|..:...||..:::....|......:|||..||..||.||
  Fly   193 SVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHGFTEGIIQKR 257

  Fly   255 I-----EAHKSGAVSTNAGDEFTRKKMAFLDT-LLSSTIDGRPLNSKELYEEVSTFMFEGHDTTT 313
            |     :|......|::|..:..::.:.|||| |||...||:||..|::.|||.|.:|.|.|.|.
  Fly   258 IDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPLTVKDIREEVDTIIFGGFDLTA 322

  Fly   314 SGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFI 378
            :.::|.:|.::.|.:.|::..:|...|.|..: ....:.:::.|:::|:..|||..|:|||.|..
  Fly   323 TTLNFFMYNMTLHPEHQQRCREEVWSVCGKDK-SEPISIEQVRQLEFLEACIKETLRMYPSGPLT 386

  Fly   379 GRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKPGPFE---YVPFSAG 440
            .|....:..|:...:|||:.:.:..:.:|..:..|.||..|:|:|:.:......|   ::||.||
  Fly   387 ARKATANCTINDFFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWAIGAEPKIEATTFIPFMAG 451

  Fly   441 PRNCIGQKFALLEIKTVVSKIIRNF 465
            .|:|:||::|::.:|.|::.::|||
  Fly   452 ARSCMGQRYAMVMLKMVLAHLLRNF 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	134/446 (30%)
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	134/447 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449060
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	10	9.900