DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and cyp46a1.2

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	XP_009292815.1	Gene:	cyp46a1.2 / 393433	ZFINID:	ZDB-GENE-040426-1184	Length:	501	Species:	Danio rerio

Alignment Length:	489	Identity:	132/489 - (26%)
Similarity:	232/489 - (47%)	Gaps:	47/489 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WFVLYIFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLP----LMGNAHQMGK----NPSEILDT 58
            |.:..||..|..:..|:|....: ...:..|::...|.|    |:|::..:.|    :.|.|.|.
Zfish     5 WVLYIIFYLLSAVFTAFLAYCLY-IHHLHQKYDHIPGPPRDNFLLGHSPSLTKAMYSDDSLIHDL 68

  Fly    59 VFSWWHQYGKDNFVFWIGT--YSNVLVTSSKYLEFILSS----QTLITKSDIYQL-THPWLGLGL 116
            ...|..:||.   |:.|.|  |..:||...:..:.||.|    :...:.|.::.| ...:||.||
Zfish    69 FLQWAEKYGP---VYRINTLHYIAILVHCPEATKTILMSPKYAKDPFSYSRLFNLFGKRFLGNGL 130

  Fly   117 LTSTGSK-WHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLD 180
            :|:.... |::.|:::.|||..:.|:......:|.|.:.:..|:.:|.........:..:.:|||
Zfish   131 VTAVDHDIWYRQRRIMDPAFSSSYLRSLISTFDEMSERLMDKLEEMANNKTPAVMHDLVNCVTLD 195

  Fly   181 VICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQD 245
            |||..|.||.:|.:..:.|....|. ::|.| .|    .|...:.|:|:.|      :..|.:|.
Zfish   196 VICKVAFGVDLNFLTQKDSPFQNAI-ELCLN-GM----ALDARDPLFRIFP------KNWKLIQQ 248

  Fly   246 FTNEIIAKRIEAHK---SGAVSTNAGDEFTRKKMAFLDTLLSSTIDGRPLNSKELYEEVS----T 303
            ..:..:..|....|   :...:...|::..:..:    |.:....:...:||.|..|::.    |
Zfish   249 IRDAAVLLRKTGEKWIQNRKTAVKNGEDVPKDIL----TQILKIAEEENVNSSEDLEQMMDNFVT 309

  Fly   304 FMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEA 368
            |...|.:||.:.:|||:..|.|:.:..::...|..||:|..   |:.:.:::.::.||...:||.
Zfish   310 FFIAGQETTANQLSFAIMALGRNPEIYKRAKAEVDEVLGTK---REISNEDLGKLTYLSQVLKET 371

  Fly   369 QRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKPGPFE 433
            .|:||:.|...|:..:|.:|:|..:|.|.::.....:....||.||||.||.||||:...|.|:.
Zfish   372 LRLYPTAPGTNRWLHEDMIINGIKIPGGCSVMFSSFVSQRLEKFFKDPLKFDPERFDENAPKPYY 436

  Fly   434 -YVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFE 466
             |.||:.|||.|:||.|:.:|.|.|::|:::.||
Zfish   437 CYYPFALGPRTCLGQVFSQMEAKVVLAKLLQRFE 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	125/456 (27%)
cyp46a1.2	XP_009292815.1	p450	39..495	CDD:278495	125/454 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810