Protein Alignment Cyp4e2 and Cyp4d20

DIOPT Version :9

• Sequence 1: NP_001286196.1
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_647723.2
• Gene: Cyp4d20 / 38311
• FlyBaseID: FBgn0035344
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 554
• Identity: 200/554 - (36%)
• Similarity: 298/554 - (53%)
• Gaps: 77/554 - (13%)

  Fly     1 MWFVLYIFLALPLLLVAYLELSTF----RRRRVL----NKFNGPRGLPLMG---NAHQMGKNPSE 54
            ||..| |..||.|||       |:    :|:|||    :...||..:|::|   .|..:|
  Fly     1 MWLTL-ITGALILLL-------TWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLG----- 52

  Fly    55 ILDTVFSW----WHQYGKDNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGLG 115
             .:.:..|    :.:||| .|.|||...|.:.....:|.|.||||.||:.|..:|:...|:|..|
  Fly    53 -AENIIGWVGEKFDKYGK-TFRFWILGESLIYTKDLQYFETILSSTTLLEKGQLYEYLRPFLNDG 115

  Fly   116 LLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLD 180
            ||.|||.|||..||:.|.||||.:|:.:.|:|:.:|:..:.:|:.||.|....|..:......||
  Fly   116 LLVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALD 180

  Fly   181 VICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTL----K 241
            ||.:.||||.:||..:.....::|.|.:.|....|.|...:|...|:.||.  |...|.|    :
  Fly   181 VITEAAMGVQVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAA--PLLHRQLLSDIR 243

  Fly   242 TLQDFTNEIIAKRIE----AHKSGA---VSTNAGDEFTRKKMAFLDTLLSSTIDGRPLNSKELYE 299
            .:.|||:::|::|.|    |...|.   :|....:..::.:||.||.||.|:|:.:||:..::.|
  Fly   244 VMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLDILLQSSINNQPLSDADIRE 308

  Fly   300 EVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLF 364
            ||.||||||.|||:||||.|:|.::||.:.|:::|:|.:.|:| .:.....|..::..:||||..
  Fly   309 EVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLG-PDASAPVTQAQLQDLKYLDCV 372

  Fly   365 IKEAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERF-ELEK 428
            |||..|:||.||.|||..:|:..|....:|..|::.|.|.....:...|.||..|||||| |.::
  Fly   373 IKETMRLYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQE 437

  Fly   429 PG--PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAE 491
            .|  .|.||||||||:||||||||:||:|.::||::|.:|:||..:||
  Fly   438 QGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEEL----------------- 485

  Fly   492 RKKRDPYRHKYDPILSAVLTLKSENGLYIRLKER 525
                       .|:|:.:  |:|.:|:.:.|:.|
  Fly   486 -----------KPMLNFI--LRSASGINVGLRPR 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	175/454 (39%)
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	181/498 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449035
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	10	9.900