DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and Cyp46a1

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	XP_006240610.1	Gene:	Cyp46a1 / 362782	RGDID:	1306605	Length:	500	Species:	Rattus norvegicus

Alignment Length:	484	Identity:	128/484 - (26%)
Similarity:	219/484 - (45%)	Gaps:	67/484 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLVAYLELSTF--RRRRVLNKFNG-PRGLPLMGNAHQMGKNP---SEILDTVF-SWWHQYGKDNF 71
            :|:|:....||  |.|.......| ||...|:|:.....|..   ..:|..|| .|..:||.
  Rat    12 VLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPYFWKKDEACGRVLQDVFLDWAKKYGP--- 73

  Fly    72 VFWIGTY--SNVLVTSSKYLEFILSSQTLITKSDIYQLTHP-----WLGLGLLTSTG-SKWHKHR 128
            |..:..:  ::|:|||.:.::..|.|......|.:|:....     ..|.||::... .:|:|.|
  Rat    74 VVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRAIQTVFGERLFGQGLVSECDYGRWYKQR 138

  Fly   129 KMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMGVSINA 193
            :::..||..:.|.......||.:.:.::.|:..|.|......|:.....|:|::...|.|:..:.
  Rat   139 RVMDLAFSRSSLVSLMGTFNEKAEQLMEILEAKADGQTPVSMQDMLTCATIDILAKAAFGMETSM 203

  Fly   194 MENRSSSIVQAFKDMCYNIN-----MRAFHPLKRNE---------LLYRLAPDYPAYSR-TLKTL 243
            :......:.||.|.|...|:     :..|.|.||.:         ||.::..|:....| .||..
  Rat   204 LLGAQKPLSQAVKVMLEGISASRNTLAKFMPGKRKQLREIRESIRLLRQVGKDWVQRRREALKRG 268

  Fly   244 QDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTIDGRPLNSKELYEEVSTFMFEG 308
            :|...:|:.:.::|.:      .|.|:         :.||.:.:               ||...|
  Rat   269 EDVPADILTQILKAEE------GAQDD---------EVLLDNFV---------------TFFIAG 303

  Fly   309 HDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYP 373
            |:|:.:.::|.|..|||..:...:|..|..||:|:.   |...::::.:::||...:||:.|:||
  Rat   304 HETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSK---RHLDYEDLGRLQYLSQVLKESLRLYP 365

  Fly   374 SVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKPGP-FEYVPF 437
            ......|..|::.:|||..||..|.|.....::|..:..|:||..|.|:||....|.| |.|.||
  Rat   366 PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPF 430

  Fly   438 SAGPRNCIGQKFALLEIKTVVSKIIRNFE 466
            |.|.|:||||:||.:|:|.|::|:::..|
  Rat   431 SLGHRSCIGQQFAQMEVKVVMAKLLQRLE 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	122/461 (26%)
Cyp46a1	XP_006240610.1	p450	34..466	CDD:278495	122/462 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810