DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e2 and Cyp4e3

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	362/525 - (68%)
Similarity:	437/525 - (83%)	Gaps:	1/525 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWFVLYIFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQ 65
            ||..:...|.|||:.:.|.|....:||::|.:||||..:|::|||:::||||:|||.|.|.||:.
  Fly     1 MWLAVLALLVLPLITLVYFERKASQRRQLLKEFNGPTPVPILGNANRIGKNPAEILSTFFDWWYD 65

  Fly    66 YGKDNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLTSTGSKWHKHRKM 130
            ||||||:||||..|::::|:.|.||:||:||.||.||.||.|.|||||.|||||.||||||||||
  Fly    66 YGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLLHPWLGHGLLTSFGSKWHKHRKM 130

  Fly   131 ITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMGVSINAME 195
            |||:|||||||||||||||||.||:..||..:|||.|.||||.|:||||||||||||||.|||||
  Fly   131 ITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMGVPINAME 195

  Fly   196 NRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAKRIEAHKS 260
            .|.|||||||:|||||||||||||.||:..::.|.|::.||.:|||||||||.:||.||:.|.::
  Fly   196 QRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFTYDIIEKRVYALQN 260

  Fly   261 GAVSTNAGDEFTRKKMAFLDTLLSSTIDGRPLNSKELYEEVSTFMFEGHDTTTSGVSFAVYLLSR 325
            |....:......||||||||||||||||||||..:|:|||||||||||||||||||||:||||||
  Fly   261 GGSKEDHDPSLPRKKMAFLDTLLSSTIDGRPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYLLSR 325

  Fly   326 HQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVIDG 390
            |.|.||||::||.||||: ::.|..:||||::|||||||||||||||||||||||:.:|||.|:|
  Fly   326 HPDVQRKLYREQCEVMGH-DMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDING 389

  Fly   391 DLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKPGPFEYVPFSAGPRNCIGQKFALLEIK 455
            .:|||||||||.|::||||:::|||||.|||||||.|||.||||:||||||||||||||||||:|
  Fly   390 SIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPAPFEYLPFSAGPRNCIGQKFALLELK 454

  Fly   456 TVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDPILSAVLTLKSENGLYI 520
            ||:||::|:||||||:|||||.||.::|.:||...|:.||:..||||||||||||||||:|||::
  Fly   455 TVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDPILSAVLTLKSDNGLHL 519

  Fly   521 RLKER 525
            ||:||
  Fly   520 RLRER 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	310/433 (72%)
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	310/433 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449013
Domainoid	1	1.000	160	1.000	Domainoid score	I1269
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	1	1.000	-	-		H111093
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	1	0.950	-	0	Normalized mean entropy	S4382
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	13	12.750