DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e2 and Cyp4ac3

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	178/522 - (34%)
Similarity:	286/522 - (54%)	Gaps:	64/522 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWFVLY--------IFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQM-GK----NP 52
            ||..|.        ::|.|..|...|..||..:|.|..:      |.||......: ||    |.
  Fly     1 MWIALLGSSLLIGALWLLLRQLNKTYFILSLCKRVRTAD------GSPLESKVFVVPGKTRFGNN 59

  Fly    53 SEILD----TVFSWWHQ-----YGKD---NFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSDIY 105
            .::|:    .:||:..:     .|::   ||:| ...|:   :..::..|.|..|..:.||:..|
  Fly    60 LDLLNLTPANIFSYIRESTAKANGQNYIWNFLF-APEYN---IVRAEDAEEIFQSTKITTKNMSY 120

  Fly   106 QLTHPWLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDF 170
            :|..|:||.|||.|...|||..||.:||||||||||.|..:..|.|.||||.|      |....|
  Fly   121 ELIRPFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKIL------DKNVGF 179

  Fly   171 QEQAHYL----TLDVICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAP 231
            :.:.:.:    ||:.||:||:||.::.| :..:...:|..|.....|.|..:||......:.|..
  Fly   180 ELELNQIIPQFTLNNICETALGVKLDDM-SEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFG 243

  Fly   232 DYPAYSRTLKTLQDFTNEIIAKRIEAHKS---GAVSTNAGDEFTRK-KMAFLDTLLSSTIDGRPL 292
            ||..|||.|:|:..|::.||.::.:..|.   |.|     |||.:| :.|.|||||::..:|: :
  Fly   244 DYKKYSRILRTIHGFSSGIIQRKRQQFKQKQLGQV-----DEFGKKQRYAMLDTLLAAEAEGK-I 302

  Fly   293 NSKELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQ 357
            :.:.:.:||:||||.|:|||::.:.|.:.||:.|.|.|.:.::|.:::  ..::...:.|| .::
  Fly   303 DHQGICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDL--PEDIDEVSMFQ-FNE 364

  Fly   358 MKYLDLFIKEAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPE 422
            :.:|:..|||:.|::||.|.|||...::.|::|.::||...:::.:..:..:.:.|..|::|.||
  Fly   365 LIHLECVIKESLRLFPSAPIIGRTCIEESVMNGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPE 429

  Fly   423 RFELEKP---GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPA--LDELVSKDGYIS 482
            ||..|..   .||.:|||||||||||||||.:||||.:::.:||||::|||  |::|..::|.:.
  Fly   430 RFLPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLEDLTFENGIVL 494

  Fly   483 TT 484
            .|
  Fly   495 RT 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	160/461 (35%)
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	164/466 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460550
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	9.000