DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e2 and Cyp26b1

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_851601.2	Gene:	Cyp26b1 / 312495	RGDID:	631379	Length:	512	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	118/546 - (21%)
Similarity:	205/546 - (37%)	Gaps:	97/546 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LALPLLLVAYLELSTFRRRRVLNKF------NGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQYG 67
            :::.|||....:|...|.....:|.      .|..|.||:|..               ..|...|
  Rat    20 VSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGET---------------GHWLLQG 69

  Fly    68 KDNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLTSTGSKWHKH-RKMI 131
            ..........|.||..|.       |..:.||..:....:....||...|.||  :|.:. |.::
  Rat    70 SGFQSSRREKYGNVFKTH-------LLGRPLIRVTGAENVRKILLGEHQLVST--EWPRSARVLL 125

  Fly   132 TPAFHFNILQDFHEVMNENSTKFIKH-----------------LKTVAAGDNIFDFQEQAHYLTL 179
            .|....|.:.|.|....:..:|...|                 |:..::.....:..::|..||.
  Rat   126 GPNTVANSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSQPEAINVYQEAQRLTF 190

  Fly   180 DVICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYP--AYSRTLKT 242
            .:.....:|.||  .|....::.:.::....|:              :.|..|.|  .|.|.::.
  Rat   191 RMAVRVLLGFSI--PEEDLGNLFEVYQQFVENV--------------FSLPVDLPFSGYRRGIQA 239

  Fly   243 LQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTID-GRPLNSKELYEEVSTFMF 306
            .|     |:.|.:|......:....|.:::..    ||.|:.|:.: |:.:..:||.:.....:|
  Rat   240 RQ-----ILQKGLEKAIREKLQCTQGKDYSDA----LDILIESSKEHGKEMTMQELKDGTLELIF 295

  Fly   307 EGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQRE--VMGNSELGRDATFQ--EISQMKYLDLFIKE 367
            ..:.||.|..:..:..|.:|.....||.:|.|.  ::.......:.|.:  .:|.::|||..|||
  Rat   296 AAYATTASASTSLIMQLLKHPAVLEKLREELRAQGLLHGGGCPCEGTLRLDMLSGLRYLDCVIKE 360

  Fly   368 AQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFEL----EK 428
            ..|::..|....|...:.:.:||..:|||.::...:........||||.:.|.|:||..    :|
  Rat   361 VMRLFTPVSGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDK 425

  Fly   429 PGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKI---------IRNFEVLPALDELVSKDGYISTT 484
            .|.|.|:||..|.|.|:|:..|.|.:|.:..::         .|.|..:..:..|...||.....
  Rat   426 DGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKF 490

  Fly   485 IGLPDAERKKRDPYRHKYDPILSAVL 510
            .|| |:.:.:..|   :.:.:|||.:
  Rat   491 FGL-DSNQNEILP---ETEAMLSATV 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	102/471 (22%)
Cyp26b1	NP_851601.2	CYP26B1	60..490	CDD:410730	101/478 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910