DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e2 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001028858.2	Gene:	Cyp4f18 / 290623	RGDID:	1305261	Length:	524	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	157/550 - (28%)
Similarity:	263/550 - (47%)	Gaps:	79/550 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WFVLYIFLALPLLLVAYL---ELSTFRRRRVLNKFNGPRGLP----LMGN-----AHQMGKNPSE 54
            |.:|.:..|..||  ||:   ..:.|...|.|.:|..|   |    |.|:     :.:.|....:
  Rat    19 WLLLLLVGASCLL--AYILPQVYAVFENSRRLRRFPQP---PTRNWLFGHLGLIQSSEEGLLYIQ 78

  Fly    55 ILDTVFSWWHQYGKDNFVFWIGTYSNVL-VTSSKYLEFILSSQTLITKSD--IYQLTHPWLGLGL 116
            .|...|       :|...:|:|.:..|: :....:::.::.:...:...|  .|:...||||.||
  Rat    79 SLSRTF-------RDVCCWWVGPWHPVIRIFHPAFIKPVILAPASVAPKDRVFYRFLKPWLGDGL 136

  Fly   117 LTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLK---TVAAGDNIFDFQEQAHYLT 178
            |.|||.||.:||.|:|||||||||:.:.::.|:::.  |.|.|   ..:.|....|..|....:|
  Rat   137 LLSTGDKWSRHRHMLTPAFHFNILKPYVKIFNDSTN--IMHAKWQRLASQGSARLDMFEHISLMT 199

  Fly   179 LDVICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTL 243
            ||.:.........|..| :.|..:.|..::...:..|....|...:|.|.|..|...:.:..:.:
  Rat   200 LDSLQKCVFSFDSNCQE-KPSEYITAILELSALVARRHQSLLLYVDLFYHLTRDGMRFRKACRLV 263

  Fly   244 QDFTNEIIAKRIEAHKSGAVSTNAGDEFTR-----KKMAFLDTLLSSTID-GRPLNSKELYEEVS 302
            .|||:.:|.:|     ...:....||:..:     |.:.|:|.||.|..: |..|:.:::..|..
  Rat   264 HDFTDAVIRER-----RRTLPDQGGDDALKAKAKAKTLDFIDVLLLSKDEHGEALSDEDIRAEAD 323

  Fly   303 TFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKE 367
            ||||.|||||.||:|:.:|.|::|.:.|.:..:|.||::.:.| ..:..:.:::|:.:|.:.|||
  Rat   324 TFMFGGHDTTASGLSWILYNLAKHPEYQERCRQEVRELLRDRE-PEEIEWDDLAQLPFLTMCIKE 387

  Fly   368 AQRVYPSVPFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFEL---EK 428
            :.|::|....|.|...:|.:: ||.::|||....:.:....:|..|:.||..:.|.||:.   |.
  Rat   388 SLRLHPPATAISRCCTQDIMLPDGRVIPKGVICRISIFGTHHNPAVWPDPEVYNPFRFDADNGEG 452

  Fly   429 PGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERK 493
            ..|..::||||||||||||.||:.|:|..::..:..|.|                   |||.:..
  Rat   453 RSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRV-------------------LPDDKEP 498

  Fly   494 KRDPYRHKYDPILSAVLTLKSENGLYIRLK 523
            :|.|           .|.|::|.||::|::
  Rat   499 RRKP-----------ELILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	135/458 (29%)
Cyp4f18	NP_001028858.2	CYP4F	74..515	CDD:410772	140/486 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348655
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650