Protein Alignment Cyp4e2 and Cyp4f18

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001028858.2
• Gene: Cyp4f18 / 290623
• RGDID: 1305261
• Length: 524
• Species: Rattus norvegicus
• Alignment Length: 550
• Identity: 157/550 - (28%)
• Similarity: 263/550 - (47%)
• Gaps: 79/550 - (14%)

  Fly     2 WFVLYIFLALPLLLVAYL---ELSTFRRRRVLNKFNGPRGLP----LMGN-----AHQMGKNPSE 54
            |.:|.:..|..||  ||:   ..:.|...|.|.:|..|   |    |.|:     :.:.|....:
  Rat    19 WLLLLLVGASCLL--AYILPQVYAVFENSRRLRRFPQP---PTRNWLFGHLGLIQSSEEGLLYIQ 78

  Fly    55 ILDTVFSWWHQYGKDNFVFWIGTYSNVL-VTSSKYLEFILSSQTLITKSD--IYQLTHPWLGLGL 116
            .|...|       :|...:|:|.:..|: :....:::.::.:...:...|  .|:...||||.||
  Rat    79 SLSRTF-------RDVCCWWVGPWHPVIRIFHPAFIKPVILAPASVAPKDRVFYRFLKPWLGDGL 136

  Fly   117 LTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLK---TVAAGDNIFDFQEQAHYLT 178
            |.|||.||.:||.|:|||||||||:.:.::.|:::.  |.|.|   ..:.|....|..|....:|
  Rat   137 LLSTGDKWSRHRHMLTPAFHFNILKPYVKIFNDSTN--IMHAKWQRLASQGSARLDMFEHISLMT 199

  Fly   179 LDVICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTL 243
            ||.:.........|..| :.|..:.|..::...:..|....|...:|.|.|..|...:.:..:.:
  Rat   200 LDSLQKCVFSFDSNCQE-KPSEYITAILELSALVARRHQSLLLYVDLFYHLTRDGMRFRKACRLV 263

  Fly   244 QDFTNEIIAKRIEAHKSGAVSTNAGDEFTR-----KKMAFLDTLLSSTID-GRPLNSKELYEEVS 302
            .|||:.:|.:|     ...:....||:..:     |.:.|:|.||.|..: |..|:.:::..|..
  Rat   264 HDFTDAVIRER-----RRTLPDQGGDDALKAKAKAKTLDFIDVLLLSKDEHGEALSDEDIRAEAD 323

  Fly   303 TFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKE 367
            ||||.|||||.||:|:.:|.|::|.:.|.:..:|.||::.:.| ..:..:.:::|:.:|.:.|||
  Rat   324 TFMFGGHDTTASGLSWILYNLAKHPEYQERCRQEVRELLRDRE-PEEIEWDDLAQLPFLTMCIKE 387

  Fly   368 AQRVYPSVPFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFEL---EK 428
            :.|::|....|.|...:|.:: ||.::|||....:.:....:|..|:.||..:.|.||:.   |.
  Rat   388 SLRLHPPATAISRCCTQDIMLPDGRVIPKGVICRISIFGTHHNPAVWPDPEVYNPFRFDADNGEG 452

  Fly   429 PGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERK 493
            ..|..::||||||||||||.||:.|:|..::..:..|.|                   |||.:..
  Rat   453 RSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRV-------------------LPDDKEP 498

  Fly   494 KRDPYRHKYDPILSAVLTLKSENGLYIRLK 523
            :|.|           .|.|::|.||::|::
  Rat   499 RRKP-----------ELILRAEGGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	138/467 (30%)
Cyp4f18	NP_001028858.2	CYP4F	74..515	CDD:410772	140/486 (29%)