Protein Alignment Cyp4e2 and CYP4V2

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_997235.3
• Gene: CYP4V2 / 285440
• HGNCID: 23198
• Length: 525
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 187/507 - (36%)
• Similarity: 275/507 - (54%)
• Gaps: 57/507 - (11%)

  Fly    37 RGLPLMGNAHQMGKNPSEILDTVFSWWHQYGKDNFV-FWIGTYSNVLVTSSKYLEFILSSQTLIT 100
            |..||:|:|..|..:..|....:..:..:|.....: .|:|....|.:.:::.:|.||:|...|.
Human    55 RAYPLVGHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQID 119

  Fly   101 KSDIYQLTHPWLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENST----KFIKHLKTV 161
            ||.:|:...||||||||||||:||...|||:||.|||.||:||.::|||.:.    |..||:...
Human   120 KSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQE 184

  Fly   162 AAGDNIFDFQEQAHYLT---LDVICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRN 223
            |.  |.|      .|:|   ||:||:||||.:|.|..|..|..|:|...|...|..|...|....
Human   185 AF--NCF------FYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWL 241

  Fly   224 ELLYRLAPDYPAYSRTLKTLQDFTNEIIAKRIEAHKSGAVSTNAGD-----EFTRKKMAFLDTLL 283
            :|.|.:..:...:.::|:.|..|||.:||:|  |::..|.....||     ....|:.||||.||
Human   242 DLWYLMFKEGWEHKKSLQILHTFTNSVIAER--ANEMNANEDCRGDGRGSAPSKNKRRAFLDLLL 304

  Fly   284 SSTID-GRPLNSKELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELG 347
            |.|.| |..|:.:::.|||.||||||||||.:.:::::|||..:.:.|:|:..|..:|.|.|:
Human   305 SVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSD-- 367

  Fly   348 RDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKV 412
            |.||.:::.:::||:..|||..|::||||...|...:|..:.|..|.|||...:....|..:.:.
Human   368 RPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRY 432

  Fly   413 FKDPHKFRPERFELEKP---GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDEL 474
            |.:|.:|:||||..|..   .|:.|||||||||||||||||::|.||::|.|:|:|.:
Human   433 FPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWI------- 490

  Fly   475 VSKDGYISTTIGLPDAERKKRDPYRHKYDPILSAVLTLKSENGLYIRLKERH 526
                           ...:||:...      |...|.|:..||::|:||.|:
Human   491 ---------------ESNQKREELG------LEGQLILRPSNGIWIKLKRRN 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	175/468 (37%)
CYP4V2	NP_997235.3	CYP4V	76..515	CDD:410773	176/478 (37%)