DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e2 and CYP4A22

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001010969.2	Gene:	CYP4A22 / 284541	HGNCID:	20575	Length:	519	Species:	Homo sapiens

Alignment Length:	539	Identity:	163/539 - (30%)
Similarity:	256/539 - (47%)	Gaps:	80/539 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LALPLLLVAYLELSTFRR--RRVLNKFNGPRGLPLMGNAH--QMGKNPSEILDTVFSWWHQYGKD 69
            |.|.|||:...:|...|:  .:.|.:|..|....|.|:..  |..:....|.:.|.::     ..
Human    25 LILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTF-----PS 84

  Fly    70 NFVFWI-GTYSNVLVTSSKYLEFILSSQTLITKSD-----IYQLTHPWLGLGLLTSTGSKWHKHR 128
            ...:|| |....|.:....|::.||.      :||     .|:...|.:|.|||...|..|.:||
Human    85 ACPYWIWGGKVRVQLYDPDYMKVILG------RSDPKSHGSYKFLAPRIGYGLLLLNGQTWFQHR 143

  Fly   129 KMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMGVSINA 193
            :|:|||||.:||:.:..:|.::....:...:.:...|:..:..:....:|||.|..:|.....:.
Human   144 RMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSI 208

  Fly   194 MENRSS-SIVQAFKDM-----CYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEII- 251
            ..:|:| |.:||..|:     |...|  |||   .|:.:|.|........|..:.....|:::|
Human   209 QVDRNSQSYIQAISDLNSLVFCCMRN--AFH---ENDTIYSLTSAGRWTHRACQLAHQHTDQVIQ 268

  Fly   252 AKRIEAHKSGAVSTNAGDEFTRKK-MAFLDTLLSSTID-GRPLNSKELYEEVSTFMFEGHDTTTS 314
            .::.:..|.|.:     ::..||: :.|||.||.:.:: |..|:.|:|..||.||||||||||.|
Human   269 LRKAQLQKEGEL-----EKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTAS 328

  Fly   315 GVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIG 379
            |:|:.:|.|:.|...|.:..:|...::|:   |...|:..:.||.|..:.||||.|:||.||.||
Human   329 GISWILYALATHPKHQERCREEIHGLLGD---GASITWNHLDQMPYTTMCIKEALRLYPPVPGIG 390

  Fly   380 RFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKPGPFE----YVPFSA 439
            |........ ||..:|||..:.|.:..|.:|.||:.:...|.|.||   .||..:    ::|||.
Human   391 RELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRF---APGSAQHSHAFLPFSG 452

  Fly   440 GPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDP 504
            |.|||||::||:.::|...:..:..||:||                          ||.|   .|
Human   453 GSRNCIGKQFAMNQLKVARALTLLRFELLP--------------------------DPTR---IP 488

  Fly   505 ILSAVLTLKSENGLYIRLK 523
            |..|.|.|||:||:::||:
Human   489 IPMARLVLKSKNGIHLRLR 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	138/455 (30%)
CYP4A22	NP_001010969.2	p450	52..505	CDD:278495	152/508 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154753
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650