DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001129072.1	Gene:	Cyp4v3 / 266761	RGDID:	708530	Length:	525	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	191/503 - (37%)
Similarity:	273/503 - (54%)	Gaps:	49/503 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 RGLPLMGNAHQMGKNPSEILDTVFSWWHQYGKDNFV-FWIGTYSNVLVTSSKYLEFILSSQTLIT 100
            |..||:|:|..|..|.:|....:..:..::.....: .|||....|.:..::.:|.||:|...|.
  Rat    55 RAYPLVGHALFMKPNNTEFFQQIIQYTEEFRHLPIIKLWIGPVPLVALYKAENVEVILTSSKQID 119

  Fly   101 KSDIYQLTHPWLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENS----TKFIKHLKTV 161
            ||.:|:...|||||||||||||||...|||:||:|||.||:||.:||||.:    .|..||:...
  Rat   120 KSFMYKFLQPWLGLGLLTSTGSKWRARRKMLTPSFHFTILEDFLDVMNEQANILVNKLEKHVNQE 184

  Fly   162 AAGDNIFDFQEQAHYLTLDVICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELL 226
            |     |:.........||:||:||||.:|.|..|..|..|:....|...|..|...|....:|.
  Rat   185 A-----FNCFFPITLCALDIICETAMGKNIGAQSNGDSEYVRTVYRMSDMIYRRMKMPWFWFDLW 244

  Fly   227 YRLAPDYPAYSRTLKTLQDFTNEIIAKRIEAHKSGAVSTNAG----DEFTRKKMAFLDTLLSST- 286
            |.:..:...:.:.||:|..|||.:||:|:.|.|:......||    ...|::| ||||.|||.|
  Rat   245 YLMFKEGRDHKKGLKSLHTFTNNVIAERVNARKAEQDCIGAGRGPLPSKTKRK-AFLDLLLSVTD 308

  Fly   287 IDGRPLNSKELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDAT 351
            .:|..|:.:::.|||.||||||||||.:.:::::|||..:.:.|||:.||..:|.|.|.  |..|
  Rat   309 EEGNKLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQRKVDKELDDVFGRSH--RPVT 371

  Fly   352 FQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDP 416
            .:::.::||||..|||..||:||||...|...:|..:.|..:.|||...:....|..:.:.|.||
  Rat   372 LEDLKKLKYLDCVIKETLRVFPSVPLFARSLSEDCEVAGYKISKGTEAVIIPYALHRDPRYFPDP 436

  Fly   417 HKFRPERFELEKP---GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKD 478
            .:|:||||..|..   .|:.|||||||||||||||||::|.||:::.|:|.|.:
  Rat   437 EEFQPERFFPENSQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILREFWI----------- 490

  Fly   479 GYISTTIGLPDAERKKRDPYRHKYDPILSAVLTLKSENGLYIRLKERH 526
                       ...:||:...      |:..|.|:..||::|:||.||
  Rat   491 -----------ESNQKREELG------LAGDLILRPNNGIWIKLKRRH 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	179/444 (40%)
Cyp4v3	NP_001129072.1	CYP4V	76..515	CDD:410773	178/474 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348400
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.750