DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and Cyp4f6

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	XP_006241111.1	Gene:	Cyp4f6 / 266689	RGDID:	708365	Length:	538	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	149/507 - (29%)
Similarity:	247/507 - (48%)	Gaps:	75/507 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LPLMGN--------AHQMGKNPSEILDTVFSWWHQYGKDNFVFWIG-TYSNVLVTSSKYLEFILS 94
            |.||.|        || :|:|               .:|..:.|:| .|..:.:.....:..:|.
  Rat    65 LTLMKNNEEGMQFIAH-LGRN---------------FRDIHLSWVGPVYPILRLVHPNVIAPLLQ 113

  Fly    95 SQTLITKSD--IYQLTHPWLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNEN-STKFIK 156
            :...:...:  :|....||||.|||.|.|.||:.||:::||||||:||:.:.::.|:: :|...|
  Rat   114 ASAAVAPKEMTLYGFLKPWLGDGLLMSAGEKWNHHRRLLTPAFHFDILKSYVKIFNKSVNTMHAK 178

  Fly   157 HLKTVAAGDNIFDFQEQAHYLTLDVICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLK 221
            ..:..|.|....|..|....:|||.:.........|..|: :|..:.|..::...|..|...|..
  Rat   179 WQRLTAKGSARLDMFEHISLMTLDSLQKCIFSFDSNCQES-NSEYIAAILELSSLIVKRQRQPFL 242

  Fly   222 RNELLYRLAPDYPAYSRTLKTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTR-----KKMAFLDT 281
            ..:.||.|..|...:.:....:.:||:.:|.:|     ...::|...|||.:     |.:.|:|.
  Rat   243 YLDFLYYLTADGRRFRKACDVVHNFTDAVIRER-----RSTLNTQGVDEFLKARAKTKTLDFIDV 302

  Fly   282 LLSSTID-GRPLNSKELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSE 345
            ||.:..: |:.|:..::..|..||||.|||||.|.:|:.:|.|:||.:.|.:..:|.||::.:.|
  Rat   303 LLLAKDEHGKGLSDVDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVRELLRDRE 367

  Fly   346 LGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYN 409
             ..:..:.:::|:.:|.:.|||:.|::|.|..|.|...:|.|: ||.::|||....:.:..:.:|
  Rat   368 -PEEIEWDDLAQLPFLTMCIKESLRLHPPVLLISRCCSQDIVLPDGRVIPKGNICVISIFGVHHN 431

  Fly   410 EKVFKDPHKFRPERFELEKP---GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPAL 471
            ..|:.||..:.|.||:.|.|   .|..::||||||||||||.||:.|||..::..:..|.|
  Rat   432 PSVWPDPEVYNPFRFDPENPQKRSPLAFIPFSAGPRNCIGQTFAMSEIKVALALTLLRFCV---- 492

  Fly   472 DELVSKDGYISTTIGLPDAERKKRDPYRHKYDPILSAVLTLKSENGLYIRLK 523
                           |||.:..:|.|           .|.|::|.||::|::
  Rat   493 ---------------LPDDKEPRRKP-----------ELILRAEGGLWLRVE 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	138/451 (31%)
Cyp4f6	XP_006241111.1	p450	53..515	CDD:278495	148/502 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348595
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650