Protein Alignment Cyp4e2 and CYP4X1

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_828847.1
• Gene: CYP4X1 / 260293
• HGNCID: 20244
• Length: 509
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 158/538 - (29%)
• Similarity: 265/538 - (49%)
• Gaps: 61/538 - (11%)

  Fly     2 WFVLYIF-LALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQ 65
            :::.::| |||.||....|.|...|..|.|..|..|.....:|:...:..:..|.|:.:.   .:
Human    14 FYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKFIQDDNMEKLEEII---EK 75

  Fly    66 YGKDNFVFWIGTYSNVL-VTSSKYLEFILSSQTLITKSD-----IYQLTHPWLGLGLLTSTGSKW 124
            |.: .|.||||.:.... :....|      ::||::::|     :.:.:.|.||.||....|.||
Human    76 YPR-AFPFWIGPFQAFFCIYDPDY------AKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKW 133

  Fly   125 HKHRKMITPAFHFNILQDFHEVMNENSTKFI--KHLKTVAAGDNIFDFQEQAHYLTLDVICDTAM 187
            .:||:::||.||||||:.:.||| .:|.|.:  |..|..:..|...:..|..:.::||:|...|.
Human   134 FQHRRLLTPGFHFNILKAYIEVM-AHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAF 197

  Fly   188 GVSINAMENRS-SSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEII 251
            ....|...|.: ....:|..::...|..|.:..|..::::::|:|....:.:..:.|..:|:.||
Human   198 SKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTII 262

  Fly   252 AKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTID-GRPLNSKELYEEVSTFMFEGHDTTTSG 315
            .:|.::.::|....|..   .||...|||.:||:..: |...:..:::.|||||:..||||..:.
Human   263 QERKKSLQAGVKQDNTP---KRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAAS 324

  Fly   316 VSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGR 380
            :|:.:|.|:.:.:.|.:..:|.|.::|:   |...|:.::.:|.|..:.|||..|:.|:||.|.|
Human   325 ISWILYCLALNPEHQERCREEVRGILGD---GSSITWDQLGEMSYTTMCIKETCRLIPAVPSISR 386

  Fly   381 FTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKPG---PFEYVPFSAGP 441
            ...|.... ||..:|.|.|:.|.:..|.:|..|:|:|..|.|.||..|...   |:.|:|||||.
Human   387 DLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGS 451

  Fly   442 RNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDPIL 506
            ||||||:||::|:|..::.|:.:|.|.|                          ||.|....|
Human   452 RNCIGQEFAMIELKVTIALILLHFRVTP--------------------------DPTRPLTFP-- 488

  Fly   507 SAVLTLKSENGLYIRLKE 524
             ....||.:||:|:.||:
Human   489 -NHFILKPKNGMYLHLKK 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	138/465 (30%)
CYP4X1	NP_828847.1	CYP4B-like	66..502	CDD:410771	142/481 (30%)
		heme binding region	447..460		10/12 (83%)