DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and Cyp3a18

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_665725.2	Gene:	Cyp3a18 / 252931	RGDID:	628709	Length:	497	Species:	Rattus norvegicus

Alignment Length:	454	Identity:	112/454 - (24%)
Similarity:	216/454 - (47%)	Gaps:	45/454 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GPRGLPLMGNAHQMGKNPSEILDTVFSWWHQYGKDNFVFWIGTYSNVLVTSSKYLEFILSSQ--T 97
            ||:.:||.|.....|....:..|..:.   :||| .:.|:.|....:.:...:.::.:|..:  :
  Rat    40 GPKPVPLFGTIFNYGDGMWKFDDDCYK---KYGK-IWGFYEGPQPFLAIMDPEIIKMVLVKECYS 100

  Fly    98 LITKSDIYQLTHP--WLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKT 160
            :.|....:   .|  ::...:..|...:|.:.|.:::|.|....|::...:|.:.....:|:|:.
  Rat   101 VFTNRRCF---GPMGFMKKAITMSEDEEWKRLRTILSPTFTSGKLKEMFPLMRQYGDTLLKNLRR 162

  Fly   161 VAAGDNIFDFQEQAHYLTLDVICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNEL 225
            ..|.....:.::.....::|||..|:.||:::::.|.....||..|.:   :..:.|.|...:.:
  Rat   163 EEAKGEPINMKDIFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKI---LKFQIFDPFLLSVV 224

  Fly   226 LYR-LAPDYPAYSRTLKTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTIDG 289
            |:. |.|.|...:.::...|..  ....|.::..|...:.:|     .:.::.||..::::.
  Rat   225 LFPFLTPIYEMLNFSIFPRQSM--NFFKKFVKTMKKNRLDSN-----QKSRVDFLQLMMNTQ--- 279

  Fly   290 RPLNSK-----------ELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGN 343
               |||           |:..:...|:|.|:|.|::.:||.:|.|:...:.|:||..|....:.|
  Rat   280 ---NSKGQESQKALSDLEMAAQAIIFIFGGYDATSTSISFIMYELATRPNVQKKLQNEIDRALPN 341

  Fly   344 SELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGY 408
            .   ...|:..:.:|:|||:.:.|:.|:||....:.|.::||..|:|..:||||.:.:.:..|..
  Rat   342 K---APVTYDALMEMEYLDMVVNESLRLYPIATRLDRVSKKDVEINGVFIPKGTVVTIPIYPLHR 403

  Fly   409 NEKVFKDPHKFRPERFELEKPG---PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLP 469
            |.:.:.:|.:|.||||..|..|   |:.|:||..|||||||.:|||:.:|..|..:::||.:.|
  Rat   404 NPEYWLEPEEFNPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQP 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	111/452 (25%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	105/424 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810