DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_663708.1	Gene:	Cyp4x1 / 246767	RGDID:	628719	Length:	507	Species:	Rattus norvegicus

Alignment Length:	528	Identity:	152/528 - (28%)
Similarity:	253/528 - (47%)	Gaps:	50/528 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LYIFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQYGKD 69
            |...|||.|:....|.|...|..|.|..|.||....|:|:...:.::..|.||.:..   :| ..
  Rat    18 LVFCLALVLMQAVKLYLRRQRLLRDLRPFPGPTAHWLLGHQKFLQEDNMEKLDEIVK---EY-PC 78

  Fly    70 NFVFWIGTYSNVL-VTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLTSTGSKWHKHRKMITP 133
            .|..|:|.:.... :....|.:..||.....|:. ::||..|:||.|||...|.:|.:||.::||
  Rat    79 AFPCWVGPFQAFFYIYDPDYAKIFLSRTDPKTQY-LHQLMTPFLGRGLLNLDGPRWFQHRCLLTP 142

  Fly   134 AFHFNILQDFHEVMNENSTKFI-KHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMGVSINAMENR 197
            |||.:||:...::|..:....: |..||....:...:..|..:.:|||:|...|.|...|...|.
  Rat   143 AFHQDILKPCVDMMAHSVNMMLDKWEKTWTTQETTIEVFEHINLMTLDIIMKCAFGQETNCQING 207

  Fly   198 S-SSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAKRIEAHKSG 261
            : .|.|:|..::...|:.|.::....::::::|:|....:....|.:...|.:||..|.:..|.
  Rat   208 TYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGKVIHQCTEKIIQDRKKTLKD- 271

  Fly   262 AVSTNAGDEFTRKKMAFLDTLLSSTI-DGRPLNSKELYEEVSTFMFEGHDTTTSGVSFAVYLLSR 325
              ..|..|  |:....|||.:||:.. |.:..:..:|..||:|||:.|||.:.:.:|:.:|.|:.
  Rat   272 --QVNQDD--TQTSQNFLDIVLSAQAGDEKAFSDADLRSEVNTFMWAGHDASAASISWLLYCLAL 332

  Fly   326 HQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVI-D 389
            :.:.|.:...|.|.::|:   |...|::::.::.|..:.|||..|:.|.:|.|.|...|...: |
  Rat   333 NPEHQDRCRTEIRSILGD---GSSITWEQLDEIPYTTMCIKETLRLIPPIPSISRELSKPLTLPD 394

  Fly   390 GDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERF---ELEKPGPFEYVPFSAGPRNCIGQKFAL 451
            |..:|.|.|:.|.:..|.:|..|:|||..|.|.||   ..|:..|..::|||:||||||||:||:
  Rat   395 GHSLPAGMTVVLSIWGLHHNPAVWKDPKVFDPLRFTKENSEQRHPCAFLPFSSGPRNCIGQQFAM 459

  Fly   452 LEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDPILSAVLTLKSEN 516
            ||:|..::..:..|.|...|..                             .|..|:...|:.::
  Rat   460 LELKVAIALTLLRFRVAADLTR-----------------------------PPAFSSHTVLRPKH 495

  Fly   517 GLYIRLKE 524
            |:|:.||:
  Rat   496 GIYLHLKK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	133/441 (30%)
Cyp4x1	NP_663708.1	CYP4B-like	66..500	CDD:410771	135/475 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348523
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750