DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e2 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus

Alignment Length:	540	Identity:	165/540 - (30%)
Similarity:	261/540 - (48%)	Gaps:	68/540 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWFVLYIFLALPLLLVAYLELSTFRRR---RVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSW 62
            :|..:.|.:.:.|.|.:.|    .||:   |.::.|.||....|.|:|.::.|..|  ||.|.||
  Rat    15 LWASVVILMVIVLKLFSLL----LRRQKLARAMDSFPGPPTHWLFGHALEIQKLGS--LDKVVSW 73

  Fly    63 WHQYGKDNFVFWIGTYSNVL-VTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLTSTGSKWHK 126
            ..|:...: ..|.|.:...| :....|.:.:.|... ...:|:|.....|:|.|||...|.||.:
  Rat    74 AQQFPHAH-PLWFGQFVGFLNIYEPDYAKAVYSRGD-PKAADVYDFFLQWIGKGLLVLDGPKWFQ 136

  Fly   127 HRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMGVSI 191
            |||::||.||:::|:.:..:..|::...:...:..|:.:..||......::.||.:.....|...
  Rat   137 HRKLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTFGKGD 201

  Fly   192 NAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAKRIE 256
            :.:.:|.:|...|..|:...:..|.......|:.:|.|.|....:.|..|...|.|:|:|.:|..
  Rat   202 SGLGHRDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACKIAHDHTDEVIRQRKA 266

  Fly   257 AHKSGAVSTNAGDEFTRKK------MAFLDTLLSSTID-GRPLNSKELYEEVSTFMFEGHDTTTS 314
            |.:         ||..|||      :.|||.||....: |..|:..||..||.||||||||||||
  Rat   267 ALQ---------DEKERKKIQQRRHLDFLDILLGVRDESGIKLSDAELRAEVDTFMFEGHDTTTS 322

  Fly   315 GVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQ--EISQMKYLDLFIKEAQRVYPSVPF 377
            |:|:.:|.::.:.:.|:...:|.|.::|:.:     :||  ::::|.||.:.:||..|:||.||.
  Rat   323 GISWFLYCMALYPEHQQLCREEVRGILGDQD-----SFQWDDLAKMTYLTMCMKECFRLYPPVPQ 382

  Fly   378 IGRFTEKDYV-IDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKPG---PFEYVPFS 438
            :.|...|... :||..:|.|:.::|.:..|..|..|:.||..|.|.||..|...   ||.::|||
  Rat   383 VYRQLNKPVTFVDGRSLPAGSLISLHIYALHRNSTVWPDPEVFDPLRFSPENAAGRHPFAFMPFS 447

  Fly   439 AGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYD 503
            |||||||||:||:.|:|.|.:..:..||.                          ..||.:.
  Rat   448 AGPRNCIGQQFAMNEMKVVTALCLLRFEF--------------------------SLDPSKM--- 483

  Fly   504 PILSAVLTLKSENGLYIRLK 523
            ||....|.|:|:||:::.||
  Rat   484 PIKVPQLILRSKNGIHLYLK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	145/447 (32%)
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	154/499 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348667
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650