Protein Alignment Cyp4e2 and Cyp4a2

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001038235.1
• Gene: Cyp4a2 / 24306
• RGDID: 2479
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 555
• Identity: 162/555 - (29%)
• Similarity: 257/555 - (46%)
• Gaps: 108/555 - (19%)

  Fly     3 FVLYIFLALPLLLVAYLELSTFRRR---RVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWH 64
            |:|.:||.|...:..||     ||:   :.|.||               ...||..|     |.|
  Rat    23 FLLSLFLVLFKAVQFYL-----RRQWLLKALEKF---------------PSTPSHWL-----WGH 62

  Fly    65 QYGKDNF---VFWI------------GTYSNVLVTSSKYLEFILSSQTLITKSD--IYQLTHPWL 112
            ......|   :.|:            |:.:.||:....|::.:|.      :||  .||...||:
  Rat    63 NLKDREFQQVLTWVEKFPGACLQWLSGSTARVLLYDPDYVKVVLG------RSDPKPYQSLAPWI 121

  Fly   113 GLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDN---IFDFQEQA 174
            |.|||...|.||.:||:|:|||||::||:.:.::|.::.:..:...:.:...|:   ||
  Rat   122 GYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVKIMADSVSIMLDKWEKLDDQDHPLEIF------ 180

  Fly   175 HYLTLDVICDTAMGVSIN-----AMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYP 234
            ||::| :..||.|..:.:     .::..|.|..:|.:|:...|..|.......|.::|.::.|..
  Rat   181 HYVSL-MTLDTVMKCAFSHQGSVQLDVNSRSYTKAVEDLNNLIFFRVRSAFYGNSIIYNMSSDGR 244

  Fly   235 AYSRTLKTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKK--MAFLDTLLSSTI-DGRPLNSKE 296
            ...|..:...:.|:.:|..|     ...:......:..|||  :.|||.||.:.: ||:.|:.::
  Rat   245 LSRRACQIAHEHTDGVIKTR-----KAQLQNEEELQKARKKRHLDFLDILLFAKMEDGKSLSDED 304

  Fly   297 LYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYL 361
            |..||.||||||||||.||:|:..|.|:.|.:.|.:..:|.:.::|:   |...|:..:.||.|.
  Rat   305 LRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGD---GTSVTWDHLDQMPYT 366

  Fly   362 DLFIKEAQRVYPSVPFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFE 425
            .:.||||.|:|..||.:.|........ ||..:|||..:.:.:..|.:|...:.:|..|.|.||.
  Rat   367 TMCIKEALRLYSPVPSVSRELSSPVTFPDGRSIPKGIRVTILIYGLHHNPSYWPNPKVFDPSRFS 431

  Fly   426 LEKP-GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPD 489
            .:.| ....|:|||.|.|||||::||:.|:|..|:..:..||:||
  Rat   432 PDSPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLP-------------------- 476

  Fly   490 AERKKRDPYRHKYDPILSAVLTLKSENGLYIRLKE 524
                  ||.|   .|:....|.|||:||:::|||:
  Rat   477 ------DPTR---IPVPMPRLVLKSKNGIHLRLKK 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	142/481 (30%)
Cyp4a2	NP_001038235.1	CYP4B-like	69..499	CDD:410771	142/479 (30%)