Protein Alignment Cyp4e2 and cyp-13A2

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_496109.1
• Gene: cyp-13A2 / 188360
• WormBaseID: WBGene00011676
• Length: 515
• Species: Caenorhabditis elegans
• Alignment Length: 513
• Identity: 121/513 - (23%)
• Similarity: 225/513 - (43%)
• Gaps: 86/513 - (16%)

  Fly     3 FVLYIFLALPL-LLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQY 66
            |||.:..::.| :|..||.:.|:..|:.:   .||||.|.:|....:.::.:..|..:..|..:|
 Worm     5 FVLAVTFSIFLGILTYYLWIWTYWMRKGV---KGPRGRPFVGVLDVLLEHETPGLIKLGEWTKKY 66

  Fly    67 GKDNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSDIY-QLTHPWLG-------LGLLTSTGSK 123
            || .:.:..||...::|.....:..|...|.    .:.| :..:|..|       :.||.:.|.:
 Worm    67 GK-VYGYTDGTQRTLVVADPAMVHEIFVKQF----DNFYGRKLNPIQGNPEKEQRVHLLAAQGYR 126

  Fly   124 WHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMG 188
            |.:.|.:.:.:|....|:.....:.:::.:.::|::...||....|........|:|||...|||
 Worm   127 WKRLRTISSQSFSNASLKKMKRTVEDSALELLRHIEKQTAGGEQIDMLRFYQEYTMDVIGRFAMG 191

  Fly   189 VSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRN----------------ELLYRLAPDYPAYS 237
            .:.:.|          ||:...|:....|...::|                :|.::. |..||:.
 Worm   192 QTDSMM----------FKNPIVNVVREIFCGSRKNLMLICQVFPPIGQFIRDLTFKF-PRIPAFK 245

  Fly   238 RTLKTLQDFTNEIIAKRI--EAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTIDG----------- 289
                 |.....:::|.||  ...:.||.|....|        |:|..|.:..|.
 Worm   246 -----LYSIMQDVVAARIAQREREKGAESGEPQD--------FIDLFLDARSDDVDFSAEAREDF 297

  Fly   290 --------RPLNSKELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSEL 346
                    :.|::.|:..:...|:..|.|||...:|:..|||:.:...|.|:.:|.....|.||:
 Worm   298 SKRNLKITKELSADEVVGQCFLFLIGGFDTTALSLSYVTYLLAVNPKIQEKVIEEIAREFGTSEV 362

  Fly   347 GRDATFQEISQMKYLDLFIKEAQRVYPSVPFI-GRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNE 410
                .|:::.::||:|..||||.|:||..... .|...|...::|..:..|..:.:....|.|:.
 Worm   363 ----EFEKLGRLKYMDCVIKEALRLYPLASISNSRKCMKTTTVNGVKIEAGVYVQMDTWSLHYDP 423

  Fly   411 KVF-KDPHKFRPERFELEKPGPFE--YVPFSAGPRNCIGQKFALLEIKTVVSKIIRNF 465
            ::: :|..:|:|||:..::|...:  |:||..|||.|||.:.|::|.|.:::.:::|:
 Worm   424 ELWGEDVKEFKPERWSTDEPLEHKGAYLPFGLGPRQCIGMRLAIMEQKILLTHLLKNY 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	102/447 (23%)
cyp-13A2	NP_496109.1	CYP3A-like	65..508	CDD:410678	104/450 (23%)