Protein Alignment Cyp4e2 and cyp-25A2

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_497776.2
• Gene: cyp-25A2 / 175495
• WormBaseID: WBGene00007964
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 540
• Identity: 146/540 - (27%)
• Similarity: 237/540 - (43%)
• Gaps: 68/540 - (12%)

  Fly     5 LYIFLALPLLLVAYLELSTFRRR---RVLNK--FNGPRGLPLMGNAHQMGKNPSEI-LDTVFSWW 63
            |.|..::.:|||:::....|.||   ::..|  ..||.....|||..|:.....:: .|....|:
 Worm     3 LLILTSILILLVSFIIYILFARREQFKLREKIGLTGPEPHWFMGNLKQIVDRKEKLGYDDSNKWF 67

  Fly    64 H----QYGKDNFVFWIGTYSNVLVTSSKYLE--FI-----LSSQTLITKSDIYQLTHPWLGLGLL 117
            :    ||| :.|..:.|...|:::::.:.::  ||     .|.:.:....|..||..     .||
 Worm    68 NELHKQYG-ETFGIYFGAQMNIVLSNEEDIKEVFIKNFSNFSDRIVPPIFDSNQLNQ-----SLL 126

  Fly   118 TST-GSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDV 181
            .:| .:.|...|..|.|.|....::...|.::.....|:..|:..|:....:|..|....|||||
 Worm   127 QNTYATGWKHTRSAIAPIFSTGKMKAMQETIHSKVDLFLDILREKASSGQKWDIYEDFQGLTLDV 191

  Fly   182 ICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPA-YSRTLKTLQD 245
            |...|..:..|...:|:.......:....||::|....:..:.:|..|||.:.| |..|  .|.|
 Worm   192 IGKCAFAIDSNCQRDRNDVFYVNARKFIANIDIRHSKVIAASFILPELAPLWRALYKYT--PLAD 254

  Fly   246 FTNEII--AKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTID-GRPLNSKELYEEVSTFMFE 307
            ....::  ...:...:.|...:::.|        .|..||:...| .:|:..:|:.|....|:..
 Worm   255 AEIPLVEGLSNVYERRRGGEGSDSVD--------LLKLLLNREDDKSKPMTKQEVIENCFAFLLA 311

  Fly   308 GHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVY 372
            |::||::.:::..||||::.:.|:||::|..|...|..|    |:..|..|||||...||..|.|
 Worm   312 GYETTSTAMTYCSYLLSKYPNVQQKLYEEIMEAKENGGL----TYDSIHNMKYLDYVYKETLRCY 372

  Fly   373 PSV-PFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFE--LEKPGPFEY 434
            |.| .||.|....|..|.|...|||:.:......:..|.:.:..|.:|.|||||  .||....::
 Worm   373 PPVIHFINRRCLADITIRGQFYPKGSVVTCLPHTVHLNPENWDSPEEFHPERFENWEEKSSSLKW 437

  Fly   435 VPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAE---RKKRD 496
            :||..|||.|:|.:||.:|.||.:.|::..||    |.:...:...|      ||..   .:.:|
 Worm   438 IPFGVGPRYCVGMRFAEMEFKTTIVKLLDTFE----LKQFKGEADLI------PDCNGVIMRPKD 492

  Fly   497 PYRHKYDPILSAVLTLKSEN 516
            |.|          |.||..|
 Worm   493 PVR----------LLLKPRN 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	126/467 (27%)
cyp-25A2	NP_497776.2	CYP3A-like	73..495	CDD:410678	124/451 (27%)