DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e2 and Cyp4f13

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_570952.1	Gene:	Cyp4f13 / 170716	MGIID:	2158641	Length:	523	Species:	Mus musculus

Alignment Length:	490	Identity:	142/490 - (28%)
Similarity:	245/490 - (50%)	Gaps:	57/490 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 KNPSEILDTVFSWWHQYGKDNFVFWIG-TYSNVLVTSSKYLEFILSSQTLITKSD--IYQLTHPW 111
            ||..|.:..:....|.: .|..:.|:| .|..:.:....::..:|.:...:...:  :|....||
Mouse    68 KNNEESMQFITHLGHDF-HDVHLSWVGPVYPILRLVHPNFIAPLLQASAAVAPKEMTLYGFLKPW 131

  Fly   112 LGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLK---TVAAGDNIFDFQEQ 173
            ||.|||.|.|.||..||:::||||||:||:.:.::.|::..  |.|.|   ..:.|.:..|..|.
Mouse   132 LGDGLLMSAGDKWSHHRRLLTPAFHFDILKSYVKIFNKSVN--IMHAKWQCLASKGTSRLDMFEH 194

  Fly   174 AHYLTLDVICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSR 238
            ...:|||.:......|..|..|: .|..:.|..::...:..|...|....:|||.|..|...:.:
Mouse   195 ISLMTLDSLQKCIFSVDSNCQES-DSKYIAAILELSSLVVKRHRQPFLYLDLLYYLTADGRRFRK 258

  Fly   239 TLKTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTR-----KKMAFLDTLLSSTID-GRPLNSKEL 297
            ....:.:||:.:|.:|     ...::|. |.||.:     |.:.|:|.||.:..: |:.|:::::
Mouse   259 ACDLVHNFTDAVIKER-----RSTLNTQ-GVEFLKAKAKTKTLDFIDVLLMAEDEHGKGLSNEDI 317

  Fly   298 YEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLD 362
            ..|..||||.|||||||.:|:.:|.|:||.:.|.:..:|.:|::.:.: ..:..:.:::|:.:|.
Mouse   318 RAEADTFMFGGHDTTTSALSWILYNLARHPEYQERCRQEVQELLRDRD-SEEIEWDDLAQLPFLT 381

  Fly   363 LFIKEAQRVYPSVPFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFEL 426
            :.|||:.|::|.|..|.|...:|.:: ||..:|||....:.:..:.:|..|:.||..:.|.||:.
Mouse   382 MCIKESLRLHPPVLLISRCCTQDVLLPDGRAIPKGNICVISIFGVHHNPSVWPDPEVYNPFRFDP 446

  Fly   427 EKP---GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLP 488
            |.|   .|..::|||||.||||||.||:.|||..::..:..|.:                   ||
Mouse   447 ENPQKRSPLAFIPFSAGTRNCIGQTFAMSEIKVALALTLLRFRI-------------------LP 492

  Fly   489 DAERKKRDPYRHKYDPILSAVLTLKSENGLYIRLK 523
            |.:..:|.|           .|.|::|.||::|::
Mouse   493 DDKEPRRKP-----------ELILRAEGGLWLRVE 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	131/434 (30%)
Cyp4f13	NP_570952.1	p450	52..513	CDD:278495	141/485 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845189
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650