DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and CYP3A5

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens

Alignment Length:	526	Identity:	137/526 - (26%)
Similarity:	245/526 - (46%)	Gaps:	82/526 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WFVLYIFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGN--AHQMG--KNPSEILDTVFSW 62
            |.:|.:.|.| |.|........|:|..:    .||..|||:||  :::.|  |..:|.
Human    12 WLLLAVSLVL-LYLYGTRTHGLFKRLGI----PGPTPLPLLGNVLSYRQGLWKFDTEC------- 64

  Fly    63 WHQYGKDNFVFWIGTYSNVL----VTSSKYLEFILSSQTLITKSDIYQL--THPWLG-LGLLTST 120
            :.:|||    .| |||...|    :|....:      :|::.| :.|.:  ....|| :|.:.|.
Human    65 YKKYGK----MW-GTYEGQLPVLAITDPDVI------RTVLVK-ECYSVFTNRRSLGPVGFMKSA 117

  Fly   121 GS-----KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLD 180
            .|     :|.:.|.:::|.|....|::...::.:.....:::|:..|........::.....::|
Human   118 ISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMD 182

  Fly   181 VICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYR-LAPDYPAYSRTLKTLQ 244
            ||..|:.||:|:::.|.....|::.|..   :......||..:.:|:. |.|.:.|.:.:|  ..
Human   183 VITGTSFGVNIDSLNNPQDPFVESTKKF---LKFGFLDPLFLSIILFPFLTPVFEALNVSL--FP 242

  Fly   245 DFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSS-----TIDGRPLNSKELYEEVSTF 304
            ..|...::|.:...|...:     ::..:.::.||..::.|     |...:.|:..||..:...|
Human   243 KDTINFLSKSVNRMKKSRL-----NDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIF 302

  Fly   305 MFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQ 369
            :|.|::||:|.:||.:|.|:.|.|.|:||.||...|:.|.   ...|:..:.||:|||:.:.|..
Human   303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNK---APPTYDAVVQMEYLDMVVNETL 364

  Fly   370 RVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKPG--PF 432
            |::|....:.|..:||..|:|..:|||:.:.:....|.::.|.:.:|.:||||||..:|..  |:
Human   365 RLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPY 429

  Fly   433 EYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELV---------------------S 476
            .|.||..|||||||.:|||:.:|..:.::::||...|..:..:                     |
Human   430 IYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDS 494

  Fly   477 KDGYIS 482
            :||.:|
Human   495 RDGTLS 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	124/457 (27%)
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	125/484 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810