DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and Cyp26a1

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_569092.2	Gene:	Cyp26a1 / 154985	RGDID:	620161	Length:	497	Species:	Rattus norvegicus

Alignment Length:	482	Identity:	113/482 - (23%)
Similarity:	195/482 - (40%)	Gaps:	75/482 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LPLLL-VAYLEL------STFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQYGK 68
            ||||| :|.|:|      |:..|...|....|..|.|..|...||.....:.|...   ..:||
  Rat    16 LPLLLFLAALKLWDLYCVSSRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMK---RRKYG- 76

  Fly    69 DNFVFWIGTYSNVLVT---SSKYLEFILSSQTLITKSDIYQLTHPW-------LGLGLLTSTGSK 123
              |::....:....|.   :......:|....|::       .| |       ||.|.|::....
  Rat    77 --FIYKTHLFGRPTVRVMGADNVRRILLGEHRLVS-------VH-WPASVRTILGAGCLSNLHDS 131

  Fly   124 WHKHR-KMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTAM 187
            .||.| |:|..||:...||.:..|:.|..:..::  :.::.|:.......:...|...:.....:
  Rat   132 SHKQRKKVIMQAFNREALQCYVPVIAEEVSGCLE--QWLSCGERGLLVYPEVKRLMFRIAMRILL 194

  Fly   188 GVS---INAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNE 249
            |..   ....|: ...:|:||::|..|              |:.|..|.| :|...:.::  ...
  Rat   195 GCEPGPAGGGED-EQQLVEAFEEMTRN--------------LFSLPIDVP-FSGLYRGVK--ARN 241

  Fly   250 IIAKRIEAH------KSGAVSTNAGDEFTRKKMAFLDTLLSSTID-GRPLNSKELYEEVSTFMFE 307
            :|..|||.:      :..|...:||.:..      |..|:..:.: |..|:.:.|.:..:..:|.
  Rat   242 LIHARIEENIRAKIRRLQAAEPDAGCKDA------LQLLIEHSWERGERLDMQALKQSSTELLFG 300

  Fly   308 GHDTTTSGVSFAVYLLSRHQDEQRKLFKE--QREVMGNSELGRDATFQEISQMKYLDLFIKEAQR 370
            ||:||.|..:..:..|..:....:|:.:|  .:.::..|........:.:.|:||:...|||..|
  Rat   301 GHETTASAATSLITYLGLYPHVLQKVREEIKSKGLLCKSHHEDKLDMETLEQLKYIGCVIKETLR 365

  Fly   371 VYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERF---ELEKPGPF 432
            :.|.||...|...|.:.::|..:|||..:...:.........|.:..:|.|:||   ..|....|
  Rat   366 LNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVADSFTNKEEFNPDRFTSLHPEDTSRF 430

  Fly   433 EYVPFSAGPRNCIGQKFA--LLEIKTV 457
            .::||..|.|:|:|::||  ||:|.||
  Rat   431 SFIPFGGGLRSCVGKEFAKILLKIFTV 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	102/451 (23%)
Cyp26a1	NP_569092.2	p450	43..491	CDD:299894	102/455 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910