Protein Alignment Cyp4e2 and Cyp4b1

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_031849.1
• Gene: Cyp4b1 / 13120
• MGIID: 103225
• Length: 511
• Species: Mus musculus
• Alignment Length: 545
• Identity: 165/545 - (30%)
• Similarity: 264/545 - (48%)
• Gaps: 78/545 - (14%)

  Fly     1 MWFVLYIFLALPLLLVAYLELSTFRRR---RVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSW 62
            :|..:.|.:...|.|::.|    |||:   |.|:.|.||....|.|:|.::.|...  ||.|.:|
Mouse    15 LWASVVILMVTVLKLLSLL----FRRQKLARALDSFPGPPKHWLFGHALEIQKTGG--LDKVVTW 73

  Fly    63 WHQYGKDNFVFWIGTYSNVL-VTSSKYLEFILSSQTLITKSD-----IYQLTHPWLGLGLLTSTG 121
            ..|:...: ..|:|.:...| :....|.:.:.|      :.|     :|.....|:|.|||...|
Mouse    74 TEQFPYAH-PLWLGQFIVFLNIYEPDYAKAVYS------RGDPKAAYVYDFFLQWIGKGLLVLEG 131

  Fly   122 SKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTA 186
            .||.:|||::||.||:::|:.:..:..|::...:...:..|:.:..||......::.||.:....
Mouse   132 PKWFQHRKLLTPGFHYDVLKPYVAIFAESTRVMLDKWEKKASENKSFDIFCDVGHMALDTLMKCT 196

  Fly   187 MGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEII 251
            .|...:.:.:..:|...|..|:...:..|.......|:.:|.|.|....:.|..:...|.|:.:|
Mouse   197 FGKGDSGLSHSDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACQIAHDHTDHVI 261

  Fly   252 AKRIEAHKSGAVSTNAGDEFTRKKMA------FLDTLLSSTID-GRPLNSKELYEEVSTFMFEGH 309
            .:|..|.:         ||..:||:.      |||.||.:..: |..|:..:|..||.|||||||
Mouse   262 RQRKAALQ---------DEKEQKKLQERRHLDFLDILLGARDESGIKLSDADLRAEVDTFMFEGH 317

  Fly   310 DTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQ--EISQMKYLDLFIKEAQRVY 372
            ||||||:|:.:|.::.:...|::..:|.||::|:    || :||  :::||.||.:.:||..|:|
Mouse   318 DTTTSGISWFLYCMALYPMHQQRCREEVREILGD----RD-SFQWDDLAQMTYLTMCMKECFRLY 377

  Fly   373 PSVPFIGRFTEKDYV-IDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEK---PGPFE 433
            |.||.:.|...|... :||..:|.|:.::|.:..|..|..|:.||..|.|.||..|.   ..||.
Mouse   378 PPVPQVYRQLSKPVTFVDGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSPENMTGRHPFA 442

  Fly   434 YVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPY 498
            ::||||||||||||:||:.|:|.|.:..:..||..|                          ||.
Mouse   443 FMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSP--------------------------DPS 481

  Fly   499 RHKYDPILSAVLTLKSENGLYIRLK 523
            :   .||....|.|:|:||:::.||
Mouse   482 K---IPIKVPQLILRSKNGIHLYLK 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	141/470 (30%)
Cyp4b1	NP_031849.1	CYP4B-like	67..501	CDD:410771	146/483 (30%)