DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e2 and CYP4F22

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_775754.2	Gene:	CYP4F22 / 126410	HGNCID:	26820	Length:	531	Species:	Homo sapiens

Alignment Length:	550	Identity:	163/550 - (29%)
Similarity:	270/550 - (49%)	Gaps:	82/550 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VLYIFLALPLLLVAYLELS-----TFRRRRVLNKFNGPRGLPLMGN-----AHQMG-KNPSEILD 57
            :|::...|..||:.:|.|.     |.||.|...:  .||...|:|:     .::.| ::..::||
Human    28 LLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQ--PPRRNWLLGHLGMYLPNEAGLQDEKKVLD 90

  Fly    58 TVFSWWHQYGKDNFVFWIGTYSNVLV-TSSKYLEFILSSQTLITKSD--IYQLTHPWLGLGLLTS 119
            .:    |..    .:.|:|....:|| ....|::.:|.:...|...|  .|....||||.|||.|
Human    91 NM----HHV----LLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLS 147

  Fly   120 TGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLK--TVAAGDNI-FDFQEQAHYLTLDV 181
            .|.||.:||:::||||||:||:.:.::.|:::.  |.|.|  .:|.|..: .|..|....:|||.
Human   148 KGDKWSRHRRLLTPAFHFDILKPYMKIFNQSAD--IMHAKWRHLAEGSAVSLDMFEHISLMTLDS 210

  Fly   182 ICDTAMGVSINAMENRS---SSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTL 243
            :.......:.|..|..|   |:|:: ...:......|..|.|   :.:|..:.|...:.:....:
Human   211 LQKCVFSYNSNCQEKMSDYISAIIE-LSALSVRRQYRLHHYL---DFIYYRSADGRRFRQACDMV 271

  Fly   244 QDFTNEIIAKRIEA-HKSGA---VSTNAGDEFTRKKMAFLDT-LLSSTIDGRPLNSKELYEEVST 303
            ..||.|:|.:|..| .:.||   :....|     |.:.|:|. ||:...||:.|:.:::..|..|
Human   272 HHFTTEVIQERRRALRQQGAEAWLKAKQG-----KTLDFIDVLLLARDEDGKELSDEDIRAEADT 331

  Fly   304 FMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEA 368
            |||||||||:||:|:.::.|:::.:.|.|..:|.:|||...|| .:..:.:::|:.:..:.|||:
Human   332 FMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGREL-EELEWDDLTQLPFTTMCIKES 395

  Fly   369 QRVYPSVPFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKP--- 429
            .|.||.|..:.|...:|..: ||.::|||....:.:....:|..|:.|...:.|.||:.:.|
Human   396 LRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQR 460

  Fly   430 GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERK- 493
            .|..||||||||||||||.||:.|::.||:..:..|.:                   ..|..||
Human   461 SPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRL-------------------SVDRTRKV 506

  Fly   494 KRDPYRHKYDPILSAVLTLKSENGLYIRLK 523
            :|.|           .|.|::||||:::::
Human   507 RRKP-----------ELILRTENGLWLKVE 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	142/457 (31%)
CYP4F22	NP_775754.2	p450	60..524	CDD:278495	153/515 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154635
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650