DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e2 and Cyp4f15

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_598888.1	Gene:	Cyp4f15 / 106648	MGIID:	2146921	Length:	534	Species:	Mus musculus

Alignment Length:	543	Identity:	152/543 - (27%)
Similarity:	254/543 - (46%)	Gaps:	68/543 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WFVLYIFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQY 66
            |.:..:.....:....|..|..|.:....|.|.|..|: :....|.:    .|:.:.|.::
Mouse    34 WLLARVLTQTYIFYRTYHHLCDFPQPPKWNWFLGHLGM-ITPTEHGL----KEVTNLVATY---- 89

  Fly    67 GKDNFVFWIGTYSNVL-VTSSKYLEFILSSQTLITKSDI--YQLTHPWLGLGLLTSTGSKWHKHR 128
             ...|:.|:|....:: :.....:..:|::...:...::  |....||||.|||.|.|.||..||
Mouse    90 -PQGFMTWLGPIIPIITLCHPDIIRSVLNASASVALKEVVFYSFLKPWLGDGLLLSDGDKWSSHR 153

  Fly   129 KMITPAFHFNILQDFHEVMNENSTKFIKHLK---TVAAGDNIFDFQEQAHYLTLDVICDTAMGVS 190
            :|:|||||||||:.:.::.|:::.  |.|.|   ..:.|....|..|....:|||.:........
Mouse   154 RMLTPAFHFNILKPYVKIFNDSTN--IMHAKWQHLASGGSARLDVFENISLMTLDSLQKCVFSFD 216

  Fly   191 INAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAKRI 255
            .|..|| .|..:.|..::...:..|....|...:.||:|......:.:....:..||:.:|..|.
Mouse   217 SNCQEN-PSEYISAILELSALVTKRYHQLLLHIDSLYQLTCSGRRFHKACHLVHSFTDAVIQDRR 280

  Fly   256 EA----HKSGAVSTNAGDEFTRKKMAFLDT-LLSSTIDGRPLNSKELYEEVSTFMFEGHDTTTSG 315
            ..    |:...:...|    ..|.:.|:|. |||...||:.|:.:::..|..||||||||||.||
Mouse   281 RTLPSKHEDDVLKAKA----KSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASG 341

  Fly   316 VSFAVYLLSRHQDEQRKLFKEQREVMGNSELGR----DATF--QEISQMKYLDLFIKEAQRVYPS 374
            :|:.:|.|:||.:.|.:..:|.:|::.:.|...    .|.|  .:::|:.:|.:.|||:.|::|.
Mouse   342 LSWILYNLARHPEYQERCRQEVQELLRDRESTEIECSCAVFLRDDLAQLPFLTMCIKESLRLHPP 406

  Fly   375 VPFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFE---LEKPGPFEYV 435
            |..|.|...:|.|: ||.::|||....:.:....:|..|:.||..:.|.||:   ::...|..::
Mouse   407 VTVISRRCTQDIVLPDGRVIPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPENIKDRSPLAFI 471

  Fly   436 PFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRH 500
            ||||||||||||.||:.|:|..::..:..|.|                   |||.:..:|.|
Mouse   472 PFSAGPRNCIGQTFAMNEMKVALALTLLRFRV-------------------LPDDKEPRRKP--- 514

  Fly   501 KYDPILSAVLTLKSENGLYIRLK 523
                    .|.|::|.||::|::
Mouse   515 --------ELILRAEGGLWLRVE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	135/454 (30%)
Cyp4f15	NP_598888.1	p450	57..526	CDD:278495	147/515 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845226
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650